RBC Disorder Matching

Question 1

shistocyte

Answer 1

microahgioathic hemolytic anemia

Question 2

polychromasia

Answer 2

reticulocytosis

Question 3

band neutrophil

Answer 3

infection

Question 4

basophilic stippling

Answer 4

lead poisoning

Question 5

acanthocyes

Answer 5

liver disease

Question 6

dole bodies

Answer 6

infection

Question 7

Howell Jolly body

Answer 7

splenectomy

Question 8

Pelter-Huet cell

Answer 8

myelodysplastic synddromes

Question 9

rouleau

Answer 9

plasma cell myeloma

Question 10

red cell agglutinates

Answer 10

cold agglutinin disease

Question 11

spherocytes

Answer 11

autoimmune hemolytic anemia

Question 12

hypochromia

Answer 12

iron deficiency anemia

Question 13

macrocytosis

Answer 13

B12 deficiency

Question 14

neutrophil hyperlobation

Answer 14

B12 deficiency

Question 15

paroxysmal nocturnal hemoglobinuria

Answer 15

clonal disorder of PIG-A gene making RBCs sensitive to complement mediated lysis

Question 16

sickle cell disease

Answer 16

point mutation resulting in abnormal hemoglobin and reduced RBC survivial

Question 17

thalassemia major

Answer 17

genetic disorder causing reduced synthesis of global chains

Question 18

warm autoimmune hemolytic anemia

Answer 18

production of RBC autoantibody causing extravascular hemolysis at body temperature

Question 19

cold agglutinin syndrome

Answer 19

production of RBC autoantibody on exposure to mycoplasma pneumoniae or EBV

Question 20

paroxysmal cold hemoglobinuria

Answer 20

autoimmune hemolytic disorder associated with IgG biphasic hemolysin

Question 21

hereditary spherocytosis

Answer 21

autosomal dominant genetic defect in ankyrin causing RBC membrane fragility

Question 22

aplastic crisis

Answer 22

red cell aplasia induced by parvovirus B19 infection

Question 23

G6PD deficiency

Answer 23

X linked enzyme deficiency resulting in acute hemolysis on exposure to oxidative compounds

Question 24

immune thrombocytopenia purpura

Answer 24

autoantibody coats patient’s platelets causing removal from circulation

Question 25

neonatal alloimmune thrombocytopenia

Answer 25

alloantibody coats patient’s platelets causing destruction

Question 26

heparin induced thrombocytopenia

Answer 26

antibody against heparin-PF4 complex leading to thrombocytopenia and thrombosis

Question 27

thrombotic thrombocytopenia purpura

Answer 27

autoantibody against ADAMTS13 leading to thrombocytopenia and MAHA

Question 28

Glanzmann thrombobasthenia

Answer 28

Genetic lack of GP2b3a platelet receptor for vWF

Question 29

bernard Soulier syndrome

Answer 29

genetic lack of GP1b platelet receptor for fibrinogen

Question 30

von Willebrand disease

Answer 30

platelet function defect where platelets do not normally bind to injured endothelium through the GP1b receptor

Question 31

Hemophilia B

Answer 31

genetic deficiency of factor 9 production

Question 32

disseminated intravascular coagulation

Answer 32

coagulopathy associated with abnormal bleeding and clotting