Anemia treatment\

Question 1

hemolytic anemia treatment

Answer 1

transfusions

EPO

Question 2

iron deficiency anemia treatment

Answer 2

ferrous sulfate

ferro-folgamma

Question 3

hepcidin

Answer 3

acute phase reactant stimulated by IL6 and TNFalpha

down regulates ferroportin leading to iron sequestration in splenic macrophages

Question 4

siltuximab

Answer 4

monoclonal IL6 antibody that decreases hepcidin expression

Question 5

tocilzumab

Answer 5

IL6 receptor antagoinst

Question 6

treatment of anemia of chronic disease

Answer 6

siltuximab
tocilzumab
steroids

Question 7

drugs causing megaloblastic anemia

Answer 7

oral contraceptives

anticonvulsants

Question 8

treatment of sideroblastic anemia

Answer 8

B6

Question 9

sickle cell treatment

Answer 9

hydroxyurea
gene insertions
L-arginine + L-n-acetyl cystein

Question 10

hydroxyurea

Answer 10

induces HbF production

Question 11

L-arginine + L-n-acetyl cysteine

Answer 11

generates NO which increases oxygenation

Question 12

drugs that cause anemia

Answer 12

chemo drugs
AZT
amphotericin B
ethanol
nitrofurantoin

Question 13

ferocon

Answer 13

iron, vitamin C, vitamin B12, folic acid, intrinsic factor

Question 14

erythropoietin

Answer 14

stimulates RBC production, from kidneys

Question 15

types of erythropoietin

Answer 15

epoetin alpha, beta, omega

darbepoetin-alpha 9

Question 16

darbopoetin-alpha 9

Answer 16

longer half life

higher potency

Question 17

indications for EPO

Answer 17

chronic renal failure
anemia in cancer patients
surgery patients
AIDS patients on AZT

Question 18

EPO cautions

Answer 18

heart disease
HTN
CHF
kidney disease/dialysis
history of stroke, heart attack, blood clots
blood cell/clotting disorder
cancer
epilepsy