Waldenstrom's Macroglobulinemia

Question 1

What 3 things are common findings on a manual differential of a patient with WM?

Answer 1

dohle bodies, plasma cells, and rouleaux

Question 2

What is the first line of therapy for increased levels of serum IgM in WM?

Answer 2

Rituximab

Question 3

What is most often found in patients with WM but not in patients with a MGUS?
a.>70 g/dl monoclonal IgM in serum
b.

Answer 3

a. >70 g/dl monoclonal IgM in serum

Question 4

Which of the following is a negative risk factor used for staging of WM?
a. monoclonal IgM

Answer 4

c. HGB

Question 5

Given the following results, predict the overall risk in developing WM.
85 years of age
serum monoclonal IgM of 1000 g/L
HGB of 10.0 g/dl

Answer 5

High Risk

Question 6

Why are plasma exchange transfusions performed in patients with WM?

Answer 6

To remove IgM from the peripheral blood

Question 7

Look at serum protein electrophoresis pattern in a patient with WM. It is a __________ gammopathy.

Answer 7

monoclonal