Sickle Cell Anemia With ESRD Flashcards
1
Q
Define sickle cell disease in relation to inheritance.
A
Sickle-shaped crescent moons and is autosomal co-dominant
2
Q
Interpret electrophoresis results in relation to hemoglobin mobility.
A
More S and F in S Disease
3
Q
What is the drug most commonly used to treat sickle cell disease?
A
Hydroxyurea
4
Q
Evaluate CBC,patient history, and lab testing in sickle cell cases…
A
Sickles etc, urinalysis- bilirubin and urobilinogen present, positive Ab screen-anti-K, anti-Cw, anti-Fya, positive Sickledex
5
Q
What is the amino acid alteration in sickle cell disease?
A
a2B2 6Glu–>Val
