Disseminated Varicella Zoster in patient with Wegner's Granulomatosis

Question 1

Describe pathologic basis of Wegner’s Granulomatosis

Answer 1

Inflammatory autoimmune disease leads to necrotizing vasculitis

Question 2

Associated disease process of Wegner’s Granulomatosis

Answer 2

Pneumonitis, chronic sinusitis, mucosal ulcerations, and renal disease… I think

Question 3

Preferred metod of treatment for Wegener’s Granulomatosis

Answer 3

Immunosuppressive therapy

Question 4

Definition of disseminated varicella zoster

Answer 4

Papovesicular rash spreading over three or more dermatomes

Question 5

Best treatment for Vzv

Answer 5

*antivirals ( nucleoside analogs: acyclovir…..)

Question 6

What lab assays would be used to confirm VZV infections for an immunocompromised patient presenting with a disseminated papovesicular rash

Answer 6

IgG, IgM, and Ag IF

Question 7

Past infection of VZV

• IF
• IgM
• IgG

Answer 7

IgG positive and antigen

Question 8

Current infection of VZV

• IF
• IgM
• IgG

Answer 8

IgM positive

Question 9

Result of varicella with IgG, IgM, and antigen IF

Answer 9

Positive IgG and antigen

Negative IgM