Fetal and Neonatal Alloimmune Thrombocytopenia

Question 1

Interpret platelet values as thrombocytopenia

Answer 1

Platelet count

Question 2

Interpret platelet values as thrombocytosis

Answer 2

platelet count >450

Question 3

State the most common antibody in fetal and neonatal alloimmune thrombocytopenia (FNAIT)

Answer 3

Most common 75-85% is from the antibody anti-HPA-1a

Question 4

State the most significant clinical symptom associated with FNAIT

Answer 4

intracranial hemorrhage

Question 5

State what is considered confirmation of a diagnosis of FNAIT- 3 items

Answer 5

1. Parental antigen passed to neonate is incompatible with the maternal circulating antibody
2. baby’s platelet count is low with no other causes
3. mother’s first pregnancy

Question 6

State the clinical symptoms of a mother of an FNAIT neonate

Answer 6

Only baby experiences clinical symptoms, not mother

Question 7

platelet counts in Glantzmann’s Thrombasthenia & FNAIT

Answer 7

GT has normal platelet counts, where FNAIT has low

Question 8

FNAIT produces ______ platelets, unlike ____

Answer 8

healthy; GT

Question 9

What is affected in FNAIT and Hemolytic disease of the fetus and newborn?

Answer 9

FNAIT: baby’s platelets, and HDFN: Red cell line

Question 10

DAT results in FNAIT

Answer 10

Negative

Question 11

DAT results in HDFN

Answer 11

Positive