ESRD preceding multiple system organ dysfunction syndrome

Question 1

List four symptoms consistent with ESRD

Answer 1

Flank pain, low urine output, fatigue, tissue swelling, poor appetite

Question 2

Recognize at least three contributing factors that lead to end-stage renal disease development.

Answer 2

medical history (Diabetes Mellitus), age (over 60), race (African American)

Question 3

Chemistry results to establish a diagnosis of renal failure.

Answer 3

Increase creatinine and BUN, decrease GFR

Question 4

Hematology results to establish a diagnosis fo renal failure.

Answer 4

Decrease HgB and HCT

Question 5

Discuss in vivo and in vitro effects of antiphospholipid antibodies.

Answer 5

In vivo, APLAs are known to cause thrombosis

In vitro effect- prolong APTT

Question 6

State the major factor that contributes to multiple organ dysfunction syndrome development.

Answer 6

disruption of normal inflammatory/anti-inflammatory response (APLAs)

Question 7

Explain why DIC is a diagnosis often included as a differential diagnosis in renal failure patients experiencing coagulopathy.

Answer 7

DIC may be triggered by organ failure or shock, MODS due to renal failure often includes anemia, which is also noted in DIC. MODS due to renal failure with coagulopathy may lead to DIC. DIC is ruled out by no schistocyte on PB.