Acute Post-streptococcal glomerulonephritis

Question 1

Explain why M-proteins contribute to the virulence of Group A beta Streptococci (GAS)

Answer 1

M-proteins on GAS cell wall have anti-phagocytic functions and responsible for virulence of organisms

Question 2

List four classic presenting symptoms of a patient with acute post streptococcal glomerulonephritis (APSGN)

Answer 2

Edema, hypertension, abdominal pain, flank pain

Question 3

State three reasons for the decreased incidence of APSGN in developed countries.

Answer 3

Decreasing in US and Europe: Proper hygiene, available antibiotics, rapid GAS tests

Question 4

Recommend the best course of treatment for a patient given the laboratory results consistent with APSGN

Answer 4

inflammation with corticosteroids
Hypertension with anti-hypertensive drugs
Electrolyte balance

Question 5

Recall the antibiotic to which 100% of GAS are susceptible

Answer 5

Penicillin

Question 6

Goodpasture’s disease Laboratory Test Results : GBM IgG EIA results:

Answer 6

> 20 EU

Question 7

APSGN Laboratory Test Results:

Answer 7

Not sure If we need to know any caz I only see patient results in notes, no smile/wink face anywhere for this lol