Disseminated Aspergillus flavus

Question 1

What is the single most predictive factor of disseminated Aspergillosis?

Answer 1

Neutropenia

Question 2

Material from a disseminated Aspergillosis infection produced yellow-brown colonies. Microscopic examination showed conidia pointing out in many directions from the vesicle with conidiophores just below the vesicle that look spiny or hairy. What is the most likely identification?

Answer 2

Aspergillus flavus.

Question 3

In which age group is acute lymphoblastic leukemia most common?

Answer 3

1-15 years

Question 4

What type of fungus is most frequently associated with infections in patients with leukemia?

Answer 4

Aspergillus species

Question 5

A dimorphic fungus shows a large, round, tuberculate macroconidia mold form at room temperature, and a yeast form produces small budding yeast at 35oC. Which organism best fits this description?

Answer 5

Histoplasmosis

Question 6

A patient presents with prolonged neutropenia, chest computerized tomography (CT) demonstrate a characteristic of halo sign, multiple nodules in kidneys, and multiple hypoattenuating lesions throughout the cerebrum and cerebellum. Predict the most probable diagnosis.

Answer 6

Disseminated Aspergillosis

Question 7

PEG-asparaginase is chemotherapy drug, known to cause an increase in which of the following?

Answer 7

ALT, AST, and Bilirubin