History in primary Amyloidosis

Question 1

State the biochemical composition of amyloid deposits

Answer 1

composed of Proteins

Question 2

Composition of abnormal protein present in primary (AL) amyloidosis

Answer 2

Light chains

Question 3

Composition of abnormal protein present in secondary (AA amyloidosis

Answer 3

Protein A

Question 4

Composition of abnormal protein present in familial (ATTR) amyloidosis

Answer 4

Transthyretin (TTR)

Question 5

Composition of abnormal protein present in senile amyloidosis

Answer 5

Transthyretin (TTR)

Question 6

List the organs or organ systems that can be affected by amyloidosis

Answer 6

Kidney, heart, liver, gastrointestinal tract, nervous system, soft tissue and skin and lung

Question 7

State the means by which amyloidosis can be definitively diagnosed

Answer 7

Biopsy/aspirate required

Question 8

State the dye used to confirm amyloid deposits in tissue

Answer 8

Congo Red dye

Question 9

List Clinical finding in Kidney

Answer 9

oedema, proteinuria, renal failure

Question 10

List Clinical finding in heart

Answer 10

dyspnea upon exertion, heart failure, arrhythmia, elevated BNP.

Question 11

List Clinical finding in liver

Answer 11

hepatomegaly

Question 12

List Clinical finding in gastrointestinal tract

Answer 12

gastrointestinal bleeding

Question 13

List Clinical finding in nervous system

Answer 13

peripheral neuropathy, autonomic neuropathy

Question 14

List Clinical finding in soft tissue and skin

Answer 14

macroglossia, arthropathy claudication (vascular amyloid), myopathy

Question 15

List Clinical finding in lung

Answer 15

dyspnea, cough