Recurrent Thrombotic Thombocytopenic Purpura (TTP) Flashcards
1
Q
Basic treatment for TTP patients
A
Plasma Exchange (requires several consecutive treatments)
2
Q
What enzyme deficiency is responsible for causing idiopathic or acquired TTP?
A
Mutation in the ADAMTS-13
3
Q
List the reference range for platelets
A
150,000-450,000/cumm
4
Q
Interpret lab results in the diagnosis of TTP
A
- Decreased ADAMTS-13
- Decreased platelets
- Decreased RBC count
- Shistocytes present on blood smear
- Increased bilirubin
- Normal PT and APTT
- classical pentad of symptoms (CNS abnormalities, Fever, microangiopathic hemolytic anemia, thrombocytopenia, renal pathology)
5
Q
What is the danger of giving platelet components for TTP patients
A
Platelets would cause further clotting in the body
6
Q
What clinical finding differentiates TTP from other microangiopathic hemolytic anemias:
- DIC
A
- decreased PT and APTT
- Decreased Fibrinogen
- Decreased Platelets
- Normal ADAMTS -13
- Positive D-Dimer
7
Q
What clinical finding differentiates TTP from other microangiopathic hemolytic anemias:
- HUS
A
- seen mostly in children
- Hematuria
- normal ADAMTS-13
- Burr cells and schistocytes on smear
- Not seen recurrently in adults
