Acquired VwD Flashcards
State the three main functions of von Willebrand antigen
- Adherence of platelets to subendothelial lining fo injured vessels
- Carrier of Factor VIII
- Providing surface area for platelet aggregation & adhesion to occur via Glycoprotein IIb/IIIa and GP Ib/IX
Discuss underlying factors that contribute to acquired VWD.
Autoimmune disease, lymphoproliferative disorders, myeloproliferative disorders.
State the expected results fo the following lab tests for a patient with acquired VWD:
PT
Normal
State the expected results fo the following lab tests for a patient with acquired VWD: APTT
Prolonged
State the expected results fo the following lab tests for a patient with acquired VWD: Mixing Studies
Corrected, indicating factor deficiency
State the expected results fo the following lab tests for a patient with acquired VWD: Platelet Count
150-450 k/cumm- normal
State the expected results fo the following lab tests for a patient with acquired VWD: Platelet aggregation with Ristocetin
Abnormal with Ristocetin
Compare propeptide antigen levels in acquired vs. congenital VWD.
Acquired propeptide levels are often normal
Congenital Propeptide levels are often decreased
List treatment options for the patients with acquired VWD.
Amicar to prevent clots from breaking down too quickly
Cytoxan- anti-cancer drug
Humate
Congenital VWD: cause of disease
Due to genetic defect
Congenital VWD: mechanism of disease
*
Congenital VWD: lab results
VWF not functioning normally, and propeptide levels are often decreased
Acquired VWD: Cause fo disease
Due to underlying conditions: Autoimmune disease, lymphoproliferative disorders, myeloproliferative disorders
Acquired VWD: Mechanism of disease
Due to decrease in synthesis, increase in proteolysis, antibody formed against VWF, increase in clearnace from circulation
Acquired VWD: Lab results
VWF & Propeptide - functioning normally
