W3 L7. Insulin Drugs

Question 1

Insulin

Answer 1

Short acting human drug

Slow onset

30 mins before meal

usually SC, IV in hyperglycemjc emergencies

Note: cant give orally!

Question 2

Lispro

Answer 2

Insulin analogue

ROSA

SC, IV (mostly SC)

15 mins before meal

Note: neutral pH

Question 3

Aspart

Answer 3

Insulin analogue

ROSA

SC, IV (mostly SC)

15 mins before meal

Note: neutral pH

Question 4

Glulisine

Answer 4

Insulin analogue

ROSA

SC, IV (mostly SC)

15 mins before meal

Note: neutral pH

Question 5

Afrezza

Answer 5

Inhaled insulin

More ROSA than insulin analogues

Note: can cause cough and throat irritation
Decreases lung function over time!!

Question 6

NPH

Answer 6

Insulin + zinc and PROTAMINE

Note: only SC!

Question 7

Glargine

Answer 7

Long acting insulin

24 hrs

pH 4.0 (cant be used in combination with insulin analogues)

Question 8

Detemir

Answer 8

Long acting insulin

24 hrs

Has fatty acid chain in it that can bind to albumin (thus prolonging half life)

Question 9

Degludec

Answer 9

Longest acting insulin

42 hrs

Has hexadecanoic acid part that forms multihexamer (probably slows down digestion of the drug)

Neutral pH (can be used with insulin analogues!)

Question 10

Lipodystrophy

Answer 10

Caused by hypoglycemia (<70 mg/ dL)

Question 11

Which Glut is insulin sensitive?

Answer 11

Glut 4

Question 12

Which characteristic of insulin drugs lower hypoglycemic risk?

Answer 12

Shorter peak effect