W3 L4. Diuretics Flashcards
Furosemide
Loop diuretic
Inhibits na+/k+/2cl-
Inc urine volume and ca2+ excretion
SE: hypo (NKMC) and inc uric acid
Same GFR, OTOTOXIC
Use: IV -> emergency
Note: excreted at OAT
Sulfonamide derivative!
Torsemide
Loop diuretic
Inhibits na+/k+/2cl-
Inc urine volume and ca2+ excretion
SE: hypo (NKMC) and inc uric acid
Same GFR, OTOTOXIC
Use: IV -> emergency
Note: excreted at OAT
Sulfonamide derivative!
Bumetamide
Loop diuretic
Inhibits na+/k+/2cl-
Inc urine volume and ca2+ excretion
SE: hypo (NKMC) and inc uric acid
Same GFR, OTOTOXIC
Use: IV -> emergency
Note: excreted at OAT
Sulfonamide derivative!
Ethacrynic acid
Loop diuretic
Inhibits na+/k+/2cl-
Inc urine volume and ca2+ excretion
SE: hypo (NKMC) and inc uric acid
Same GFR, OTOTOXIC
Use: IV -> emergency
Note: excreted at OAT
Chlorothiazide
Thiazide diuretic
Inhibits na+/cl-
Inc urine volume and DEC ca2+ excretion
SE: hypo (NKM) and hyper (CU)
Dec GFR
Use: hypertension, edema and hypercalcemia (urinary calcium oxalate stone)
Sulfonamide derivative!
Hydrochlorothiazide
Thiazide diuretic
Inhibits na+/cl-
Inc urine volume and DEC ca2+ excretion
SE: hypo (NKM) and hyper (CU)
Dec GFR
Use: hypertension, edema and hypercalcemia (urinary calcium oxalate stone)
Sulfonamide derivative!
Chlorthalidone
Thiazide diuretic
Inhibits na+/cl-
Inc urine volume and DEC ca2+ excretion
SE: hypo (NKM) and hyper (CU)
Dec GFR
Use: hypertension, edema and hypercalcemia (urinary calcium oxalate stone)
Thiazide like
Indapamide
Thiazide diuretic
Inhibits na+/cl-
Inc urine volume and DEC ca2+ excretion
SE: hypo (NKM) and hyper (CU)
Dec GFR
Use: hypertension, edema and hypercalcemia (urinary calcium oxalate stone)
Thiazide like
Metolazone
Thiazide diuretic
Inhibits na+/cl-
Inc urine volume and DEC ca2+ excretion
SE: hypo (NKM) and hyper (CU)
Dec GFR
Use: hypertension, edema and hypercalcemia (urinary calcium oxalate stone)
Thiazide like
Spironolactone
Potassium sparing diuretic
Inhibits aldosterone receptor
SE: Gynecomastia
Use: hypokalemia (+ thiazide/ loop diuretic), edema, resistant hypertension
Eplerenone
Potassium sparing diuretic
Inhibits aldosterone receptor
SE: Gynecomastia
Use: hypokalemia (+ thiazide/ loop diuretic), edema, resistant hypertension
Triamterene
Potassium sparing diuretic
Inhibits sodium channels
SE: dec sodium and inc potassium
Use: hypokalemia (+thiazide/ loop diuretics)
Do not change urine volume!
(Not used for hypotension?)
Amiloride
Potassium sparing diuretic
Inhibits sodium channels
SE: dec sodium and inc potassium
Use: hypokalemia (+thiazide/ loop diuretics)
Do not change urine volume!
(Not used for hypotension?)
-zolamide
Carbonic anhydrase inhibitors
Treat altitude sickness and Glaucoma
SE: acidosis
Which drug causes ototoxicity?
Loop diuretics