L8. Cyclooxygenase

Question 1

• profen

Answer 1

NSAID

Propionic acid

Non selective cox inhibitor

Use: Anti inflammatory, antipyretic, analgesic

Question 2

Diflunisal

Answer 2

NSAID

Salicylic acid

Non selective cox inhibitor

Use: anti-inflammatory, antipyretic, analgesic

Question 3

Salsalate

Answer 3

NSAID

Salicylic acid

Non selective cox inhibitor

Use: anti-inflammatory, antipyretic, analgesic

Question 4

Naproxen

Answer 4

NSAID

Propionic acid

Non selective cox inhibitor

Use: anti-inflammatory, antipyretic, analgesic

Question 5

• ac

Answer 5

NSAID

Acetic acid

Non selective cox inhibitor

Use: anti-inflammatory, antipyretic, analgesic

Question 6

Indomethacin

Answer 6

NSAID

Acetic acid

Non selective cox inhibitor

Use: anti-inflammatory, antipyretic, analgesic

Question 7

• oxicam

Answer 7

NSAID

Enolic acid

Non selective cox inhibitor

Use: anti-inflammatory, antipyretic, analgesic

Question 8

• fenamic

Answer 8

NSAID

Fenamates

Non selective cox inhibitor

Use: anti-inflammatory, antipyretic, analgesic

Question 9

• coxib

Answer 9

Selective cox 2 inhibitors

Use: anti-inflammatory, antipyretic, analgesic

Question 10

Celecoxib

Answer 10

Selective cox 2 inhibitor

Low risk of asthma

Only one used in vascular stroke

Question 11

Paracetamol

Answer 11

Acetaminophen

Inhibits cox in CNS

Antipyretic and analgesic

Produces napqi

Question 12

N acetylcysteine

Answer 12

Treats NAPQI associated hepatic necrosis

Upon depletion of glutathione can become toxic to liver

Question 13

Aspirin

Answer 13

Salicylic acid

Antiplatelet CV protection

Irreversible inhibitor of Cox 1 (low dose)

Anti inflammatory
(High dose)

Question 14

Non selective cox inhibitors

Use?

Side effects?

CI?

Answer 14

Use: anti-inflammatory, antipyretic, analgesic

SE:
GI mucosa (ulcers etc)
Dec kidney GFR
Inc CVD risk
Inc asthma risk

CI: pregnancy
Premature closure of the ductus arteriosus

Question 15

Selective cox2 inhibitors

Use?

SE?

CI?

Answer 15

Use: anti-inflammatory, antipyretic, analgesic

SE:
Dec kidney GFR
Inc CVD risk
Inc asthma risk

CI: pregnancy
Premature closure of the ductus arteriosus

Question 16

Non selective vs selective cox inhibitor difference?

Answer 16

SE for non selective:
Gastric mucosa (ulcers etc)

SE for selective:
Asthma risk is lower

Question 17

Cox 1 functions

Gastric | kidney | CV | injury

Answer 17

Gastric:
PGE2 - protective

Kidney:
Afferent artery vasoD - inc GFR

CV:
TXA2 - clot formation, vasoD

Injury:
X

Question 18

Cox 2 functions

Gastric | kidney | CV | injury

Answer 18

Gastric:
X

Kidney:
Afferent artery vasoD - inc GFR

CV:
PGI2 - inhibit clot, VasoC

Injury:
Inflammation, pain and fever

Question 19

Napqi

Made non toxic with? (Endogenous)

Treated with?

Answer 19

Non toxic w/ glutathione in liver

Treated w/ N acetylcysteine