L8. Cyclooxygenase Flashcards
- profen
NSAID
Propionic acid
Non selective cox inhibitor
Use: Anti inflammatory, antipyretic, analgesic
Diflunisal
NSAID
Salicylic acid
Non selective cox inhibitor
Use: anti-inflammatory, antipyretic, analgesic
Salsalate
NSAID
Salicylic acid
Non selective cox inhibitor
Use: anti-inflammatory, antipyretic, analgesic
Naproxen
NSAID
Propionic acid
Non selective cox inhibitor
Use: anti-inflammatory, antipyretic, analgesic
- ac
NSAID
Acetic acid
Non selective cox inhibitor
Use: anti-inflammatory, antipyretic, analgesic
Indomethacin
NSAID
Acetic acid
Non selective cox inhibitor
Use: anti-inflammatory, antipyretic, analgesic
- oxicam
NSAID
Enolic acid
Non selective cox inhibitor
Use: anti-inflammatory, antipyretic, analgesic
- fenamic
NSAID
Fenamates
Non selective cox inhibitor
Use: anti-inflammatory, antipyretic, analgesic
- coxib
Selective cox 2 inhibitors
Use: anti-inflammatory, antipyretic, analgesic
Celecoxib
Selective cox 2 inhibitor
Low risk of asthma
Only one used in vascular stroke
Paracetamol
Acetaminophen
Inhibits cox in CNS
Antipyretic and analgesic
Produces napqi
N acetylcysteine
Treats NAPQI associated hepatic necrosis
Upon depletion of glutathione can become toxic to liver
Aspirin
Salicylic acid
Antiplatelet CV protection
Irreversible inhibitor of Cox 1 (low dose)
Anti inflammatory (High dose)
Non selective cox inhibitors
Use?
Side effects?
CI?
Use: anti-inflammatory, antipyretic, analgesic
SE: GI mucosa (ulcers etc) Dec kidney GFR Inc CVD risk Inc asthma risk
CI: pregnancy
Premature closure of the ductus arteriosus
Selective cox2 inhibitors
Use?
SE?
CI?
Use: anti-inflammatory, antipyretic, analgesic
SE:
Dec kidney GFR
Inc CVD risk
Inc asthma risk
CI: pregnancy
Premature closure of the ductus arteriosus
