L9. Steroid Pharmacology

Question 1

Zileuton

Answer 1

5-LOX inhibitor

LOX pathway inhibitor

Question 2

-lukast

Ex: zafirlukast

Answer 2

Lox receptor antagonists

Question 3

Lipocortin

Answer 3

PLA2 inhibitor

Hugs phospholipids in ca2 dep manner

Activated by glucocorticoids (cortisol etc)

Question 4

PLA2

Answer 4

Phospholipase 2

Converts membrane phospholipids to arach acid

Question 5

Licorice

Answer 5

11 - beta HSD inhibitor

Causes pseudohyperaldosteronism

Question 6

11 - beta HSD

Answer 6

Protects mineralocorticoid receptor from cortisol

Question 7

Fludrocortisone

Answer 7

Mineralocorticoid drug

Mostly MC
Little AI

Question 8

Deoxycorticosterone

Answer 8

Mineralocorticoid drug

MC activity only!

Question 9

Hydrocortisone

Answer 9

Glucocorticoid drug

Equal AI and MC activity

Short acting!

Question 10

Cortisone

Answer 10

Glucocorticoid drug

Equal AI and MC activity

Short acting

Question 11

Prednisone

Answer 11

Glucocorticoid drug

Mostly AI

Intermediate acting

Question 12

Prednisolone

Answer 12

Glucocorticoid drug

Mostly AI

Intermediate acting

Question 13

Methyl - prednisolone

Answer 13

Glucocorticoid drug

Mostly AI

Intermediate acting

Question 14

Triamcinolone

Answer 14

Glucocorticoid drug

INHALED!

AI only!

Intermediate acting

Question 15

Beta methasone

Answer 15

Glucocorticoid drug

Intensely AI only!

Long acting

IM within 48 hrs of expected premature delivery!

Accelerates lung maturation of premature baby

Question 16

Dexamethasone

Answer 16

Glucocorticoid

Intensssely AI only!

Long acting

IM within 48 hrs of expected premature delivery

Can be used to diagnose cushings!

(Cortisol levels don’t lower after admin -> you have cushing’s boy!)

Question 17

Beclomethasone

Answer 17

Inhaled corticosteroids

Affinity 1

First pass 80

Question 18

Budenoside

Answer 18

Inhaled corticosteroid

Affinity 10

First Pass 90

Question 19

Fluticasone

Answer 19

Inhaled corticosteroid

Affinity 20

First Pass 99

Question 20

Ketoconazole

Answer 20

Adrenocorticoid inhibitors

Anti fungal

Inhibits Gonad and adrenal hormone synthesis

Question 21

Etomidate

Answer 21

Adrenocorticoid inhibitors

Sedative/ anesthetics

Inhibits glucocorticoid synthesis

Question 22

Spironolactone

Answer 22

Adrenocorticoid inhibitors

Anti hypertensive

Inhibits mineralocorticoid receptors

Question 23

Mifepristone

Answer 23

Adrenocorticoid inhibitors

Contragestive

Inhibits glucocorticoid receptors

Question 24

Replacement therapy for primary, secondary and tertiary adrenocorticoid insufficiency

Answer 24

Use corticosteroids!!

Note: primary adrenocorticoid insufficiency - addisons

Question 25

Advantage of ICS (inhaled cortico...) over oral corticosteroids for allergies?

Answer 25

Reduces systemic effects

Question 26

Corticosteroid Side effects?

Answer 26

``` Glaucoma L U C Osteoporosis CUSHINGS syndrome O Retardation of growth T INFECTIONS (immune suppressant) C Oedema (water retention) I DIABETES mellitus (hyperglycemia) S ```

Question 27

Corticosteroids proper dosage?

Answer 27

Alternate day | Taper down

Question 28

Use of inhaled corticosteroids?

Answer 28

Asthma