Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pharmacology Exam 2 > L9. Steroid Pharmacology > Flashcards

L9. Steroid Pharmacology Flashcards

1
Q

Zileuton

A

5-LOX inhibitor

LOX pathway inhibitor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

-lukast

Ex: zafirlukast

A

Lox receptor antagonists

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Lipocortin

A

PLA2 inhibitor

Hugs phospholipids in ca2 dep manner

Activated by glucocorticoids (cortisol etc)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

PLA2

A

Phospholipase 2

Converts membrane phospholipids to arach acid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Licorice

A

11 - beta HSD inhibitor

Causes pseudohyperaldosteronism

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

11 - beta HSD

A

Protects mineralocorticoid receptor from cortisol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Fludrocortisone

A

Mineralocorticoid drug

Mostly MC
Little AI

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Deoxycorticosterone

A

Mineralocorticoid drug

MC activity only!

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Hydrocortisone

A

Glucocorticoid drug

Equal AI and MC activity

Short acting!

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Cortisone

A

Glucocorticoid drug

Equal AI and MC activity

Short acting

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Prednisone

A

Glucocorticoid drug

Mostly AI

Intermediate acting

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Prednisolone

A

Glucocorticoid drug

Mostly AI

Intermediate acting

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Methyl - prednisolone

A

Glucocorticoid drug

Mostly AI

Intermediate acting

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Triamcinolone

A

Glucocorticoid drug

INHALED!

AI only!

Intermediate acting

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Beta methasone

A

Glucocorticoid drug

Intensely AI only!

Long acting

IM within 48 hrs of expected premature delivery!

Accelerates lung maturation of premature baby

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Dexamethasone

A

Glucocorticoid

Intensssely AI only!

Long acting

IM within 48 hrs of expected premature delivery

Can be used to diagnose cushings!

(Cortisol levels don’t lower after admin -> you have cushing’s boy!)

17
Q

Beclomethasone

A

Inhaled corticosteroids

Affinity 1

First pass 80

18
Q

Budenoside

A

Inhaled corticosteroid

Affinity 10

First Pass 90

19
Q

Fluticasone

A

Inhaled corticosteroid

Affinity 20

First Pass 99

20
Q

Ketoconazole

A

Adrenocorticoid inhibitors

Anti fungal

Inhibits Gonad and adrenal hormone synthesis

21
Q

Etomidate

A

Adrenocorticoid inhibitors

Sedative/ anesthetics

Inhibits glucocorticoid synthesis

22
Q

Spironolactone

A

Adrenocorticoid inhibitors

Anti hypertensive

Inhibits mineralocorticoid receptors

23
Q

Mifepristone

A

Adrenocorticoid inhibitors

Contragestive

Inhibits glucocorticoid receptors

24
Q

Replacement therapy for primary, secondary and tertiary adrenocorticoid insufficiency

A

Use corticosteroids!!

Note: primary adrenocorticoid insufficiency - addisons

25
Q

Advantage of ICS (inhaled cortico…) over oral corticosteroids for allergies?

A

Reduces systemic effects

26
Q

Corticosteroid Side effects?

A 
Glaucoma
L
U
C
Osteoporosis
CUSHINGS syndrome
O
Retardation of growth
T
 INFECTIONS (immune suppressant)
C
Oedema (water retention)
 I
DIABETES mellitus (hyperglycemia)
S
27
Q

Corticosteroids proper dosage?

A

Alternate day

Taper down

28
Q

Use of inhaled corticosteroids?

A

Asthma

Pharmacology Exam 2 (14 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions