W3 L6. Anticoagulants

Question 1

Warfarin

Answer 1

Anticoagulant (extrinsic)

Oral

Inhibits VKOR - C1
(2,7,9,10) and C,S

Delayed onset

Not used in pregancy

Question 2

Heparin

Answer 2

Anticoagulant (intrinsic)

Pentasacch: Activates AT III (inhibits FX)
18 oligo: Inhibits F II

Immediate onset

Can be used in pregnancy

SE: HIT

Question 3

HIT treatment

Answer 3

DTI

Question 4

Warfarin antagonist

Answer 4

Vit K and FFP

Question 5

Heparin antagonist

Answer 5

Protamine

PF IV

Question 6

INR increase (agents)

Answer 6

Protein binding drugs

Antibiotics

Question 7

Intrinsic

Vit K?

Answer 7

Independent

Question 8

Extrinsic

Vit K?

Answer 8

Dependent

Question 9

INR decrease (agents)

Answer 9

Vit K foods (leafy greens)

Question 10

PTT

Answer 10

Heparin monitor

Question 11

• rudin

Answer 11

Direct thrombin inhibitor

Can treat HIT

IV

Question 12

Dabigatran

Answer 12

Direct thrombin inhibitor

Oral

Question 13

Idarucizumab

Answer 13

DTI inhibitor

Question 14

Apixaban

Answer 14

Direct FX inhibitor

Question 15

Rivaroxaban

Answer 15

Direct FX inhibitor

Question 16

Andexxa (factor Xa)

Answer 16

Direct FX inhibitor antagonist

Question 17

• grel

Answer 17

Anti platelet drug

Thienopyridine

P2Y12/ ADP receptor blocker

90% broken down by esterase

Activation by first pass effect

Oral

Question 18

Abciximab

Answer 18

Anti platelet drug

Antibody against GP IIb/ IIIa

IV

Question 19

Ticagrelor

Answer 19

Anti platelet drug

Thienopyridine

P2Y12/ ADP receptor blocker

90% broken down by esterase

Doesn’t require Activation by first pass effect

Oral

Question 20

Tirofiban (eptifbatide)

Answer 20

Anti platelet drug

Non peptide GP IIb/ III a

IV

Question 21

Dipyridamole

Answer 21

Anti platelet drug

Adenosine reuptake inhibitor

Increases camp

Oral

Question 22

Xanthine

Answer 22

Dipyridamole action inhibitor (blocks adenosine receptors)

Question 23

• kinase (ex streptokinase)

Answer 23

Plasminogen activator

Binds in 1:1 complex w/ plasminogen to activate other plasminogen

Inhibits Factor V and Factor VII

IV

Question 24

• teplase (ex ateplase)

Answer 24

Plasminogen activator

Activates plasminogen bound to fibrin

CLOT specificity!!

IV

Question 25

Aminocaproic acid

Answer 25

Inhibits plasminogen activators - kinase and - teplase

Question 26

Glanzmanns thrombasthenia

Answer 26

Defect in GP IIb/ IIIa

Question 27

Platelet activation factors

Answer 27

Add adrenalin to trash 5 Tee Pees ``` ADP Adrenalin TXA2 5-HT Thrombin PAF ```

Question 28

Platelet inactivation factors

Answer 28

Need a CAP like a G ``` NO cAMP Adenosine PGI2 cGMP ```