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Pharmacology Exam 2 > W3 L6. Anticoagulants > Flashcards

W3 L6. Anticoagulants Flashcards

1
Q

Warfarin

A

Anticoagulant (extrinsic)

Oral

Inhibits VKOR - C1
(2,7,9,10) and C,S

Delayed onset

Not used in pregancy

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2
Q

Heparin

A

Anticoagulant (intrinsic)

Pentasacch: Activates AT III (inhibits FX)
18 oligo: Inhibits F II

Immediate onset

Can be used in pregnancy

SE: HIT

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3
Q

HIT treatment

A

DTI

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4
Q

Warfarin antagonist

A

Vit K and FFP

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5
Q

Heparin antagonist

A

Protamine

PF IV

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6
Q

INR increase (agents)

A

Protein binding drugs

Antibiotics

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7
Q

Intrinsic

Vit K?

A

Independent

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8
Q

Extrinsic

Vit K?

A

Dependent

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9
Q

INR decrease (agents)

A

Vit K foods (leafy greens)

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10
Q

PTT

A

Heparin monitor

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11
Q
  • rudin
A

Direct thrombin inhibitor

Can treat HIT

IV

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12
Q

Dabigatran

A

Direct thrombin inhibitor

Oral

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13
Q

Idarucizumab

A

DTI inhibitor

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14
Q

Apixaban

A

Direct FX inhibitor

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15
Q

Rivaroxaban

A

Direct FX inhibitor

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16
Q

Andexxa (factor Xa)

A

Direct FX inhibitor antagonist

17
Q
  • grel
A

Anti platelet drug

Thienopyridine

P2Y12/ ADP receptor blocker

90% broken down by esterase

Activation by first pass effect

Oral

18
Q

Abciximab

A

Anti platelet drug

Antibody against GP IIb/ IIIa

IV

19
Q

Ticagrelor

A

Anti platelet drug

Thienopyridine

P2Y12/ ADP receptor blocker

90% broken down by esterase

Doesn’t require Activation by first pass effect

Oral

20
Q

Tirofiban (eptifbatide)

A

Anti platelet drug

Non peptide GP IIb/ III a

IV

21
Q

Dipyridamole

A

Anti platelet drug

Adenosine reuptake inhibitor

Increases camp

Oral

22
Q

Xanthine

A

Dipyridamole action inhibitor (blocks adenosine receptors)

23
Q
  • kinase (ex streptokinase)
A

Plasminogen activator

Binds in 1:1 complex w/ plasminogen to activate other plasminogen

Inhibits Factor V and Factor VII

IV

24
Q
  • teplase (ex ateplase)
A

Plasminogen activator

Activates plasminogen bound to fibrin

CLOT specificity!!

IV

25
Q

Aminocaproic acid

A

Inhibits plasminogen activators

  • kinase and - teplase
26
Q

Glanzmanns thrombasthenia

A

Defect in GP IIb/ IIIa

27
Q

Platelet activation factors

A

Add adrenalin to trash 5 Tee Pees

ADP
Adrenalin
TXA2
5-HT
Thrombin
PAF
28
Q

Platelet inactivation factors

A

Need a CAP like a G

NO
cAMP
Adenosine
PGI2
cGMP

Pharmacology Exam 2 (14 decks)

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