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Pharmacology Exam 2 > W3 L3. Lipid Lowering drugs > Flashcards

W3 L3. Lipid Lowering drugs Flashcards

1
Q
  • statin
A

HMG CoA reductase inhibitors

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2
Q

Rosuvastatin

A

HMG CoA reductase inhibitors

Most potent and efficacious (1 of 2)

Non cyp450 (dec drug to drug rxns)

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3
Q

Atorvastatin

A

HMG CoA reductase inhibitor

Most potent and efficacious (1 of 2)

3A4 metabolism

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4
Q

Lovastatin

A

HMG CoA reductase inhibitor

3A4 metabolism

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5
Q

Simvastatin

A

HMG CoA reductase inhibitor

3A4 metabolism

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6
Q

Pravastatin

A

HMG CoA reductase inhibitor

Non cyp450 (dec drug to drug rxns)

Dec incidence of myalgias, myopathy and rhabdo

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7
Q

Pitavastatin

A

HMG CoA reductase inhibitors

Non cyp450 (dec drug to drug rxns)

Dec incidence of myalgias, myopathy and rhabdo

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8
Q

Fluvastatin

A

HMG CoA reductase inhibitors

2C9 metabolism

Dec incidence of myalgias, myopathy and rhabdo

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9
Q

Ezetimibe

A

Cholesterol absorption inhibitor

Inhibits NPC 1L1
absorbs cholesterol in GI

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10
Q

Alirocumab

A

PCSK9 inhibitor

(Enzyme produced in liver)

Inhibits degradation of cholesterol R

(1 of 2)

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11
Q

Evolocumab

A

PCSK9 inhibitor

(Enzyme produced in liver)

Inhibits degradation of cholesterol R

(1 of 2)

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12
Q

Cholestyramine

A

Bile acid sequestrant

Removes bile (dec cholesterol)

May increase TG levels

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13
Q

Colestipol

A

Bile acid sequestrant

Removes Bile (dec cholesterol)

May increase TG levels

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14
Q

Colesevelam

A

Bile acid sequestrant

Removes Bile (dec cholesterol)

May increase TG levels

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15
Q

Niacin

A

Hormone sensitive lipase inhibitor

Dec LDL and triglycerides
POTENT inc in HDL

SE: intense cutaneous FLUSH (can use aspirin to prevent this) and hyperurecimia (inhibits secretion of uric acid)

(Note: fibrates inc HDL as well)

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16
Q

Fenofibrate

A

PPAR alpha inhibitor

Inc Lipoprotein lipase
Dec apo CIII

Dec TG and inc HDL

More effective than gemfibrozil in lowering triglyceride levels

Also increase billiary cholesterol excretion
(predisposed to form gallstones!!)

17
Q

Gemfibrozil

A

Fibrate - PPAR inhibitor

Inc LPL
Dec apo CIII

Dec TG and inc HDL

Less effective than fenofibrate and lowering TG

Also increase billiary cholesterol excretion (predisposed to form gallstones)

18
Q

Dyslipidemia serum fat levels?

A

TG, LDL, TC go up

HDL goes down

19
Q

Grapefruit juice inhibits which enzyme?

A

CYP3A4

20
Q

What is SAMS?

A

Statin associated muscle symptoms

21
Q

Do combination of gemfibrozil, niacin and statins have adverse effects? If so on what? If not then skip the exam.

A

Increase in risk of muscle adverse effects

22
Q

Familial hypercholestolemia treatment? (2)

A

PCSK 9 inhibitors
and
Niacin

Pharmacology Exam 2 (14 decks)

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