L4. H2 Receptor Blocker

Question 1

• tidine

Answer 1

H2 receptor antagonist

Question 2

Misprostol

Answer 2

Prostaglandin (synthetic)

Prevention of NSAID induced ulcers!

SE: uterine contractions in pregnancy
Cramps, abd pain, diarrhea

Question 3

• prazole

Answer 3

PPI

Use: NSAID ulcers
H pylori
Zollinger ellison (hypersecretion)
Duodenal ulcer
GERD

SE: fracture risk,
Clostridium difficile
Dec Vit B12 and CaCO3 abs

Cyp2C19 inhibitors

Question 4

Ketoconazole env req?

Answer 4

Acidic

Question 5

Cimetidine

Answer 5

H2 receptor antagonist

SE: gynecomastia and galactorrhea, testicular atrophy

Inhibits cyp1A2, 2C9 and 2D6

Only h2 antagonist w/ endocrine and anti androgenic side effects

Question 6

Ranitidine

Answer 6

H2 receptor antagonist

Weaker inhibition on hepatic metabolism (compared to cimetidine)

CNS effects (altered mentation in elderly patients on IV administration)

Question 7

Proton pump activators

Answer 7

Ach, His, gastrin

Question 8

Proton pump inhibitor (endogenous)

Answer 8

PGE2