Pharmacokinetics Flashcards
Which number of doses makes any drug reach equilibrium?
5
What happens to drug concentration once you above 5 doses?
Stays the same
(200% of original)
No matter how many extra doses
Which drugs are potent inducers of hepatic metabolism?
Seizure drugs
2C9 metabolizes which drugs? (3)
Inhibited by? (1)
Met:
NSAIDs
Warfarin
Phenytoin
Inhibited:
Fluconazole
2D6 metabolizes? (3)
Inhibited by? (4)
Metabolism:
Codeine
Most beta blockers
Most TCA
Inhibited: Fluoxetine Haloperidol Paroxetine Quinidine
3A4 metabolizes? (6)
Inhibited by? (4)
Induced by? (6)
Metabolism: Most Ca2+ blockers Most BDZ Most statins Cyclosporine Most 2nd gen antihistamines Cisapride
Inhibited: -azole antifungals Cimetidine Erythromycin Grapefruit Juice
Induced: Barbi Phen Carbamazepine Glucocorticoids Rifampin St johns wort
2C19 metabolizes? (3)
Inhibited by? (2)
Metabolism:
Diazepam
Phenytoin
Omeprazole
Inhibited:
Omeprazole
Ketoconazole
Drugs secreted by OAT?
3 - 4 - 2
Penicillin
Cephalosporine
Penicillin
-zolamide
Chlorothiazide
Furosemide
Bumetanide
Aspirin
Indomethacine
Drugs secreted by OCT?
2 - 1
Cimetidine
Ranitidine
Amiloride
Zero order definition?
More drug = longer action
T 1/2 depends on amount
Ex heparin and aspirin
First order?
A constant fraction of drug is eliminated/ unit time
T I/2 constant
1A2 metabolizes? (2)
Inhibited by?
Induced by?
Metabolism:
Xanthines
Clozapine
Inhibited by:
Cimetidine
Fluvoxamine
Induced by:
Smoking, bbq, barbi, phen, carbamazepine
Best absorbed gastric?
Weak acids
Un ionized and will be absorbed well
Best intestinal absorption?
Weak base
Un ionized and will be abs well
Why is naloxone added to opioid tablets?
So they don’t crush and take IV
if they did naloxone wouldn’t be metabolized and the opioid effect would be inhibited
