W3 L5. ACE Inhibitors And ARBs Flashcards
1
Q
- pril
A
Ace inhibitor
Important for HF and hypertension!
Dec (PASym)
Dec left ventricular hypertrophy
Dec remodelling
SE: cough and angioedema Renal insufficiency (dec GFR) and hyperkalemeia Metabolic acidosis and hypotension
Use: diabetic nephropathy
Renal artery hypotension
Note: slow progression of HF
CI: renal artery stenosis
+aldesterone antagonist/ k+ sparing diuretics
2
Q
Captopril and enalopril
Hepatic metabolism required?
A
Nope, the rest do
3
Q
- sartan
A
ARB (ang 2 R blocker)
Inhibits ang2 EFFECT
SE: renal insufficiency and hyperkalemia and hypotension
Not first line for HF
4
Q
Aliskiren
A
Direct renin inhibitor
Inhibits conversion of angiotensinogen to ang 1
5
Q
Effects of bradykinin? (3)
A
Vasodilation, cough and angiedema
