vulvar/vaginal disease Flashcards
musty, fishy odor with incr thin gray-white to yellow discharge; mild vulvar irritation, pH >4.5
BV
incr in WBC, loss of normal lactobacilli, clue cells “ ground glass”
BV
gold standard for BV
gram stain
clinical dx of BV made with 3/4 of what criteria
- abnormal gray discharge
- pH >4.5
- whiff test
- clue cells
BV tx (2)
- oral or topical metronidazole
2. topical clindamycin
itching, burning, external dysuria, dyspareunia, thick odorless cottage cheese, pH 4-5
candida
dx of candida
visualization of blastospores or pseudohyphae on saline or KOH microscopy
tx of candida
vaginal application of imidazole, miconazole, clotrimazole, terconazole
what sort of azole to use in pregnancy for tx of candida infxn
oral fluconazole
if recurrence of candida within 1 month of tx
oral fluconazole x 6 mon
tx of T glabrata
intravaginal boric acid capsules or gentian violet
where does trich live?
vagina, skene ducts, urethra
transmission of trich
sexual, pools, hot tubes
trich pH
> 4.5
appearance of vulva with trich
edema or erythema
strawberry cervix
trich
dx of trich
- microscopic exam
2. nucleic acid probe test
trich tx
oral metronidazole or tinidazole
tx of trich in pregnancy
oral metronidazole or tinidazole
atrophy of vaginal epithelium due to decr estrogen levels
atrophic vaginitis
expected pH in atrophic vaginitis
> 4.7
decr vaginal discharge, dryness, ithcing, burning, dyspareunia, urinary urgency, recurrent UTI
atrophic vaginitis
tx of atrophic vaginitis (2)
- local water-based moisterizers
2. topical or oral estrogen tx
pruritis that can interfere with sleep, pruritis ani, inflammatory process
lichen sclerosis
tx of lichen sclerosis
- improve general care
2. superpotent steroid ointment (clobetasol)
an itch that rashes
lichen simplex chronicus
develops secondary to an irritant dermatitis
lichen simplex chronicus
labia majora/minora and perineal body can be diffusely reddened with occ hyperplastic plaques of red-brown
lichen simplex chronicus
tx of lichen simplex chronicus
- d/c irritant
- antipruritic: diphenhydramine or hydroxyzine + mod strength steroid cream
- antidepressant
presents as a desquamative lesion of the vagina on the inner labia minora and vuvlar vestibule
lichen planus
whitish lacy bands or keratosis (wickham striae)
lichen planus
presents with chronic vulvar burning, insertional dyspareunia, profuse vaginal discharge
lichen planus
does biopsy of lichen planus show any atypia?
no
tx of lichen planus
topical steroids
between lichen simplex chronicus and lichen planus, which requires a shorter course of tx?
lichen planus
between lichen simplex chronicus and lichen planus, which is more likely to recur?
lichen planus
tx of psoriasis
- coal tar + UV light
2. topical steroids
inflammatino of sebaceous glands with lesions that are pale red to yellow-pink; may be covered by oil appearing scaly crust
seborrheic dermatitis
tx of vulvar dermatitis
- remove offending agent
- 5% soln Al acetate
- topical corticosteroids
small smooth nodular material on vulva that may be excised
sebaceous (inclusion) cysts
collection of peritoneal fluid within round ligament insertion into labia majora
cyst of the canal of nuck
when to tx bartholin’s gland cyst with Abx
+ N. gonorrhea OR cellulits
premalignant conditions of the vulva
- paget’s disease
2. Vulvar intraepithelial neoplasia (VIN)
chronic pruritis, velvety-red lesions that become eczematous & scar into white plaques, age >60
paget’s disease
tx of paget’s disease
wide local excision
dx of VIN
colposcopy + biopsy
tx of VIN
wide local excision or laser excision
f/u of VIN: colposcopy every____ until
every 6 months until disease free x 2 years
most common type of vulvar cancer
squamous cell carcinoma
where is vulvar cancer usus found?
labia majora
dx of vulvar cancer
need to have annual exam & do a biopsy if indicated
tx of vulvar cancer
wide local excision with inguinal lymph node dissection
how to dx premalginant disease of vagina
- PAP
- colposcopy
- biopsy
tx of VaIN
local resection, laser ablation or 5FU
in utero exposure to DES assc’d with
clear cell adenocarcinoma
peak incidence for vaginal cancer
age 60
watery, blood tinged vaginal discharge, postmenopausal bleeding, vaginal pruritis
vaginal cancer
tx of stage I, II vaginal cancer
surgical resection
tx of stage III, IV vaginal cancer
radiation