endocrinology Flashcards
avg duration of female monthly cycle
20-45 days
endometrial proliferation takes place during follicular or luteal phase?
follicular
follicular phase is followed by____, luteal phase is followed by_____
ovulation; menses
when does the corpus luteum form?
luteal phase
GnRH is released in what sort of manner?
pulsatile
there is a pulsatile release of LH every____
90 min
FSH rises ________
early in follicular phase
peak concentrations of steroids occur when?
right before ovulation
where are inhibin A & B synthesized?
granulosa cells of ovary
inhibin A is secreted from____, Inhibin B is secreted from____
corpus luteum; granulosa cells
inhibin B regulates ant pit to decr secretion of_____
FSH
follicular phase is associated with_____synthesis
estrogen
during the follicular phase, proliferation of the uterin endometrium is regulated by?
estrogen
what induces ovulation?
the surge of FSH & LH at day 14
what hormone is absoultely req’d for ovulation?
LH
what is a temporary endocrine gland?
corpus luteum
when does the corpus luteum reach a mature state?
7-8 days following ovulation
what is the regulatory hormone of steroid synthesis in luteal phase?
LH
what is the regulatory hormone of steroid synthesis in follicular phase?
LH & FSH
differentiation of the uterine endometrium is regulated by?
progesterone
what exerts negative feedback at the end of the luteal pahse?
- progesterone
2. inhibin A
break down of the zona pellucida
hatching
trophoblastic cells of the blastocyst makes contact with endometrium
apposition
trophoblasts differentiates into (2)
- cytotrophoblasts
2. syncytiotrophoblasts
what cell types sends out protrusions and invades the endometrium
syncytiotrophoblasts
what stimualtes ovarian steroidogenesis for 1st 8 weeks after implantation?
HcG
when does hcg production peak?
10 weeks
think of what hormone for growth, development, metabolism of fetus?
hpl
what happens to hpl over the course of pregnancy?
increases
_______produce both Hcg and hpl
syncytiotrophoblasts
hpl starts getting secreted at ______
6 weeks
CRH is produced by _____and____
syncytiotrophoblasts and trophoblasts
what hormone induces the onset of labor and PG production?
CRH
what hormone inhibs PG production and suppresses uterine contraction?
progesteron and 17-OH progesterone
what provides substrates for estrogen synthesis?
DHEA
