Von Willebrands disease (VWD) Flashcards
What type/pattern of bleeding occurs in VW disease?
Clotting type
What is the most common inherited bleeding disorder?
Von Willebrand’s disease
What chromosme is mutated in VWD?
Chromsome 12
What are the clinical faetures of VWD?
Epistaxis
Bleeding after burshing teeth
Excessive bleeding after surgery
Eaily brusing
Menorrhagia
Haemathrosis
What condition should you always rule out for when a patient presents with VWD?
Lukaemia
What investigations are done for VWD?
APTT (activated partial thromboplastin time)
PTT (partial thromboplastin time)
What mode of inheritance is VWD?
Autosomal dominant
What are the treatments for VWD?
Desmopressin
Blood transfusions
If a girl with VWD has menorrhagia, what treatment can be given?
OCP
What are the functions of VW factor (VWF)?
Primary homeostasis
Fibrin clot fomration
Platlet aggregation
What are the 3 different types of VWD?
Type 1 -> Qualitve issue (too little VWF)
Type 2 -> Quality issue (VWF is of a shit quality)
Type 3 -> Absence (VWF is just no where to be seen ehhh)
Where are the bleeding sites for VWD?
Muscous membranes (nose, gums…)
Skin
Can both boys and girls get VWD?
Yeah
It’s not X-linked bruv
For how long does epitaxis occur in VWD?
>10mins
What does VWF molecule look like?
Long and colied
