VIRO: MEpt2 ADENOVIRIDAE Flashcards
DESCRIBE ADENOVIRIDAE
non-enveloped, dsDNA
replication of adeno
nucleus
What type of inclusion bodies?
intranuclear
what does adenos mean?
gland
Quail bronchitis
- Causative Agent
Quail bronchitis virus (QBV), an Adenovirus (Aviadenovirus)
Transmission of Quail bronchitis
Direct contact with infected birds
* Airborne transmission through respiratory secretions
* Contaminated feed, water, and equipment
Clinical Signs of Quail bronchitis
Respiratory distress (coughing, sneezing, rales)
* Conjunctivitis and ocular discharge
* Decreased feed intake, lethargy
* High mortality in young quails
Pathogenesis of Quail bronchitis
- The virus targets respiratory epithelium, leading to inflammation and
secondary bacterial infections. - Severe cases result in pneumonia, tracheitis, and impaired oxygen
exchange.
Egg-drop syndrome
- Causative Agent
Egg Drop Syndrome Virus (EDSV-76), an Adenovirus (Atadenovirus,
Duck Adenovirus 1
Transmission of Egg-drop syndrome
Vertical transmission (from infected hens to eggs)
* Horizontal transmission via contaminated water, feces, fomites
reservoirs Egg-drop syndrome
Wild birds (such as ducks)
Clinical Signs of Egg-drop syndrome
Drop in egg production (soft-shelled, misshapen, or shell-less eggs)
* Normal appetite and no respiratory distress
* Loss of pigmentation in brown eggs
Pathogenesis of Egg-drop syndrome
The virus infects oviduct epithelium, impairing egg formation and shell
deposition.
* Infected birds remain carriers, shedding the virus in feces and
reproductive secretions.
Equine adenoviruses
Equine Adenovirus Type 1 (EAdV-1)
Equine Adenovirus Type 2 (EAdV-2)
Primarily affects the respiratory
tract.
Equine Adenovirus Type 1 (EAdV-1)
Primarily affects the
gastrointestinal tract
Equine Adenovirus Type 2 (EAdV-2)
Transmission of Equine adenoviruses
- Direct contact with infected horses
- Respiratory droplets, fecal-oral route
- Contaminated water, feed, and equipment
Clinical Signs of Equine adenoviruses
- Mild respiratory infection (cough, nasal discharge, fever)
- Conjunctivitis, pharyngitis
- Gastrointestinal upset (EAdV-2)
- Severe pneumonia in immunocompromised foals (SCID foals)
Pathogenesis Equine adenoviruses
The virus replicates in epithelial cells of the respiratory and digestive
tracts, causing mild to severe inflammation.
* Immunocompromised foals (e.g., those with Severe Combined
Immunodeficiency - SCID) may develop fatal pneumonia due to
uncontrolled viral replication
Causative Agent of - Infectious Canine Hepatitis (ICH)
Canine Adenovirus Type 1 (CAV-1)
Transmission of Canine Adenovirus Type 1 (CAV-1)
- Direct contact with infected urine, saliva, or feces
- Contaminated food, water, fomites
- Can persist in the environment for weeks to months
Clinical Signs of Canine Adenovirus Type 1 (CAV-1)
Fever, lethargy, vomiting, diarrhea
* “Blue Eye” (corneal edema due to immune complex deposition)
* Jaundice (liver failure), petechial hemorrhages
* Severe cases: Seizures, coma, sudden death
Pathogenesis
CAV-1 infects hepatocytes and endothelial cells, leading to necrosis,
hemorrhage, and DIC (disseminated intravascular coagulation).
* The virus also damages the kidneys, causing prolonged urinary
shedding.
Canine Infectious Tracheobronchitis (“Kennel
Cough”) Causative Agent
Canine adenovirus type 2 (CAV-2)
Transmission of Canine adenovirus type 2 (CAV-2)
Aerosolized droplets from coughing dogs
* Direct contact with infected saliva, nasal discharge
Clinical Signs of Canine adenovirus type 2 (CAV-2)
Dry, hacking cough, retching
* Nasal discharge, mild fever
* Self-limiting in healthy dogs but severe in puppies or
immunocompromised dogs
Pathogenesis of Canine adenovirus type 2 (CAV-2)
CAV-2 infects upper respiratory tract epithelium, causing
inflammation and predisposing dogs to secondary bacterial infections
(e.g., Bordetella bronchiseptica).
* Often part of kennel cough complex with Bordetella, parainfluenza
virus, and Mycoplasma.
