Viral hepatitis Flashcards
What is the transmission of Hep A?
Faecal oral
Vowels from the bowels
What are the clinical features of hep A?
Usually acute infection Jaundoce fatigue fever Anorexia Itch
What investigations are done for hep A?
IgM- elevated in acute stage
What is the management of hep A?
Immunisation
How is hep B transmitted?
B= Blood and bodily fluids
What are the clinical features of hep B?
DNA virus ~10% become chronic chronic infection Jaundice fever Fatigue Anorexia Itch
What investigations are done for Hep B?
IgM= + in acute IgG= + in chronic HBsAg= infected with hep B HBsAb= protected via past infection or immunisation HBcAb= past or current infection Hep B viral DNA= indicated viral load
What is the management of hep B?
Pegylated interferon
Antiviral
What is the prevention of hep B/
Immunisation for those at risk
What are the complications of hep B?
~10% become chronic
Progression to cirrhosis
Main cause of hepatocellular carcinoma worldwide
What is the transmission of Hep C?
C= circulation
Most prevalent in UK
What are the clinical features of hep C/
RNA virus Jaundice Fatigue fever Anorexia Itch
What investigations are done for Hep C?
HCV antibody
Hep C RNA= indicated viral load
What is the management f hep C?
Direct acting antivirals
What are the complications of hep C?
3/4 become chronic
Progression to cirrhosis
Main cause of hepatocellular carcinoma in Europe
