Coeliac Flashcards
1
Q
What is coeliac?
A
Autoimmune condition causing sensitivity to Gladin fraction of gluten via tissue transglutaminase
2
Q
What is the histology in coeliac?
A
Partial or subtotal villous atrophy
Increase in intraepithelial lymphocytes
3
Q
What are the signs and symptoms of coeliac?
A
Weight loss Diarrhoea and/or constipation Abdo pain Blating Anaemia Fatigue Dermatitis herpetiformis
4
Q
What is dermatitis herpetiformis?
A
Intensely itchy skin condition, usually symmetrical on extensor surfaces
5
Q
How is coeliac diagnosed?
A
Coeliac serology- anti tissue transglutaminase, IgA
HLA status- + in 97% coeliacs
Distal duodenal biopsy for villous atrophy
6
Q
How is coeliac managed?
A
Withdraw gluten and refer to state registered dietician
7
Q
What is refractory coeliac?
A
Doesn’t respond to withdrawal of gluten
8
Q
How is refractory coeliac managed?
A
Steroids
9
Q
What are the complications of coeliac?
A
Refractory coeliac Increased risk of -Oesophagel carcinoma -Small bowel adenocarcinoma/lymphoma -Bowel cancer
