VIII - Skin Flashcards
Outermost layer of integument, stratified squamous epithelial layer of ectodermal origin, devoid of blood vessels and consists of 4-5 layers
epidermis
Connective tissue layer of mesodermal origin below the epidermis and its basement membrane
dermis
Dermis: loose, comparatively cell-rich connective tissue, fills the hollows at the deep surface (dermal papillae) of the epidermis, capillaries are frequent, collagen fibers are finer
papillary layer
Dermis: appears denser and contains fewer cells, thick collagen fibers that aggregate into bundles
reticular layer
Layer of loose vascular connective tissue infiltrated by adipocytes
hypodermis
Skin: production of keratin protein, squamous epithelial cells
keratinocyte
Skin: important in formation of endogenous sunscreen, sound in basal layer and in hair follicles
melanocyte
Skin: epidermal dendritic cells, antigen presenting cells
Langerhan cells
Skin: serve as mechanoreceptors or a neuroendocrine function
Merkel cells
Disorder in which melanocytes are destroyed, autoimmune
Vitiligo
Disorder in which melanocytes are unable to synthesize melanin either due to abscence of tyrosinase activity or inability to take up tyrosine
Albinism
Skin Layers from most superficial
corneum, lucidum, granulosum, spinosum, basale
Skin Layers: superficial stratum layer consisting of 20-30 layers of dead, flat, anucleated and cornified/keratinized cells filled with keratin filaments (horny cells) embedded in a densematrix of proteins
Stratum Corneum
Skin Layers: spaces between cells are filled with lipids making a continuous membrane, protects against friction and water loss
Stratum Corneum
Skin Layers: 2-3 layers of transitional cells of flat eosinophilic anucleated cells, only found in regions of thick stratum corneum of palms and soles
Stratum Lucidum