Video11 pb Drug Side Effects.

Question 1

A 34-year-old man in the hospital is being treated for a severe MRSA (Methicillin Resistance Staphylococcus Aureus Osteomyelitis) when he develops a full body cutaneous flushing.
What is causing the flushing?

Answer 1

Red man syndrome caused byVancomycin as a treatment. Also it is caused by Niacin, Adenosine, Dihydropyridine CCBs.

Question 2

What drugs have a coronary vasospasm as a potential side effect?

Answer 2

Cocaine, amphetamines, methamphetamines (-triptans) and Ergotamine.

Question 3

What drugs have a dilated cardiomyopathy as a potential side effect?

Answer 3

Doxorubicin and Daunorubicin.

Question 4

What drugs have a Torsades de pointes as a potential side effect?

Answer 4

Class III potassium channel blockers, Class IA sodium channel blockers, Macrolides, Haloperidol, Chloroquine and Protease inhibitors.

Question 5

A 44-year-old woman is in the hospital for a deep venous thrombosis of her right lower leg. After a several days of treatment her platelet count drops to 30,000 per microliter.
What drugs have Thrombocytopenia as a potential side effect?

Answer 5

Heparin and Cimetidine (H2 blocker).

Question 6

What drugs have Agranulocytosis as a potential side effect?

Answer 6

Clozapine, Carbamazepine, Colchicine, PTU, Methimazole and Dapsone.

Question 7

What drugs have Aplastic anemia as a potential side effect?

Answer 7

Chloramphenicol, Benzene, NSAIDs, Propylthiuracil (PTU) and Methimazole.

Question 8

What drugs have Gray baby syndrome as a potential side effect?

Answer 8

Chloramphenicol.

Question 9

What drugs have Hemolysis in G6PD-deficient patients as a potential side effect?

Answer 9

Isoniazid, Sulfonamides, Primaquine, High-dose aspirin, Ibuprofen, Nitrofurantoin, Dapsone, Fava beans and Naphthalene.

Question 10

What drugs have Thrombosis as a potential side effect?

Answer 10

Oral contraceptive pills (OCP).

Question 11

A 56-year-old man presents slowly worsening shortness of breath over the past several months. He denies cough, fever or any other ill-like symptom. He has a PMHx (Past Medical History) of atrial fibrillation.

Answer 11

Amiodarone develops a Pulmonary fibrosis. Other medications are Bleomycin and Busulfan.

Question 12

What drugs have cough as a potential side effect?

Answer 12

ACE inhibitors.

Question 13

A 32-year-old woman presents with several days of worsening bloody diarrhea and abdominal pain. About 2-3 weeks ago the patient was ill with a sore throat for which she received treatment.
What does she have? What causes it?

Answer 13

Pseudomembranous colitis caused by Clindamycin or Amoxicillin/Ampicillin.

Question 14

What drugs have Focal to massive hepatic necrosis as a potential side effect?

Answer 14

Halothane, Acetominophen, Valproic acid and Amanita Phalloides (mushroom toxin).

Question 15

What drugs have Hepatitis as a potential side effect?

Answer 15

INH (Isoniazid)

Question 16

A 66-year-old man presents with a progressive enlarging breast tissue. He has a PMHx of CHF (Chronic Heart Failure). What is the drug?

Answer 16

He has Gynecomastia caused by Spirinolactone. Also is caused by Digoxin, Estrogens, Cimetidine, Chronic alcohol use, Ketoconazole, Marijuana.

Question 17

What drugs have Adrenocortical insufficiency as a potential side effect?

Answer 17

Withdrawal of corticosteroids.

Question 18

What drugs have Hot flashes as a potential side effect?

Answer 18

Tamoxifen and Clomiphene.

Question 19

What drugs have Hypotiroidism as a potential side effect?

Answer 19

Amiodarone, Lithium and Sulfonamides.

Question 20

A 50-year-old man presents with a swollen, red and painful right first toe. This began spontaneously. He has a PMHx of Diabetes, HTN and Dyslipidemia. What mess are we thinking here?

Answer 20

Gout: Furosemide, Thiazides, Niacin, Cyclosporin, Pyrazinamide.

Question 21

What drugs have Gingival hyperplasia as a potential side effect?

Answer 21

Phenytoin and Verapamil.

Question 22

What drugs have Osteoporosis as a potential side effect?

Answer 22

Corticosteroids and Heparin.

Question 23

What drugs have Photosensitivity as a potential side effect?

Answer 23

Sulfonamides, Amiodarone and Tetracycline.

Question 24

What drugs have Stevens-Johnson syndrome as a potential side effect?

Answer 24

Seizure drugs: Ethosuximide, Carbamazepine, Lamotrigine, Phenytoin and Phenobarbital.
Sulfa drugs, Penicillin and Allopurinol.

Question 25

What drugs have drug-induced SLE as a potential side effect?

Answer 25

Sulfonamides, Hydralazine, Isoniazid, Procainamide and Phenytoin.

Question 26

What drugs have Tendon rupture/cartilage damage as a potential side effect?

Answer 26

Fluoroquinolones

Question 27

A 27-year-old woman presents with fever, dysuria and lower back pain. Her labs show a creatinine of 2.5, eosinophiluria and urine With Cell casts. She has PMHx of HTN and Chronic lower back pain. What do you think here?

Answer 27

Interstitial nephritis associated with NSAIDs, Furosemide and Antibiotics.

Question 28

What drugs have Diabetes Insipidus as a potential side effect?

Answer 28

Lithium and Demeclocycline

Question 29

What drugs have Fanconi Syndrome as a potential side effect?

Answer 29

Expired tetracycline and Heavy metal exposure.

Question 30

What drugs have Hemorrhagic cystitis as a potential side effect?

Answer 30

Cyclophosphamide and Ifosfamide.

Question 31

A 58-year-old man presents with new onset tremor in the hands. He has a PMHx of Diabetes, HTN and Chronic nausea.

Answer 31

He has Gastroparesis treat with Metoclopramide.

Parkinson-like syndrome is caused by Metoclopramide, Antipsychotics and Reserpine.

Question 32

What drugs have Cinchonism as a potential side effect?

Answer 32

Quinidine or Quinine.

Question 33

What drugs have seizures as a potential side effect?

Answer 33

Bupropion, Imipenem/cilastin, Tramadol, Metoclopramide and Benzodiazepine or alcohol withdrawal.

Question 34

What drugs have Tardive Dyskinesia as a potential side effect?

Answer 34

Antipsychotics

Question 35

What drugs have Disulfiram-like reaction as a potential side effect?

Answer 35

Metronidazole, Certain cephalosporins, Procarbazepine, First generation sulfonylureas and Disulfiram.

Question 36

Which drugs Cause Nephrotoxicity and Neurotoxicity as well?

Answer 36

Aminoglycosides, displaying and polymyxin.

Question 37

Which drugs Cause Nephrotoxicity and Ototoxicity as well?

Answer 37

Aminoglycosides, Vancomycin, Loop diuretics and Cisplatin.

Question 38

Which drugs Cause Anticholinergic effects?

Answer 38

Atropine, TCAs, H1-blockers, Thioridazine and Chlorpromazine.

Question 39

What medication causes cardiotoxicity and bone marrow suppression?

Answer 39

Doxorubicin and Daunorubicin.

Question 40

An African-American man that goes to Africa develops anemia after taking prophylactic medicine for primary disease prevention. What enzyme is this patient deficiency?

Answer 40

G6PD deficiency

Question 41

A 65-year-old male patient taking multiple medication presents with Gynecomastia. Which medal could be responsible for this patient’s Gynecomastia?

Answer 41

Spironolactone and Ketoconazole.

Question 42

A patient presents with tinnitus, dizziness, headache, and GI distress. What drug is causing these symptoms?

Answer 42

Quinine and Quinidine.

Question 43

What medication are known for causing drug-induced lupus?

Answer 43

Sulfonamides, Hydralazine, Isoniazid, Procainamide and Phenytoin.