Video 3 Sympathetic Activation Flashcards
Which are the sympathetic nervous system receptors?
Alpha: 1 & 2.
Beta: 1 & 2.
What is the effect of the sympathetic nervous system on the eyes? And which receptor is used?
Alpha1: Increase the pupillary dilator muscle contraction (Mydriasis).
Alpha2: Decrease aqueous humor production.
Beta2: Increase aqueous humor production.
What is the effect of the sympathetic nervous system on the vascular system? And which receptor is used?
Alpha1: Increase vascular smooth muscle contraction.
Beta2: Cause Vasodilation.
What is the effect of the sympathetic nervous system on the pressure? And which receptor is used?
Alpha1: Increase peripheral resistance and blood pressure.
What is the effect of the sympathetic nervous system on the GI tract and GU? And which receptor is used?
Alpha1: increase intestinal and bladder sphincter muscle contraction.
What are the functions of the Alpha 2 receptor in the, sympathetic pathetic nervous system?
Decrease insulin release, lipolysis.
Increase platelet aggregation.
Which are the effects of the sympathetic Beta 1 receptors?
Tachycardia, increase lipolysis, myocardial contractility and release of renin.
What are the effects of Beta 2 receptors?
Vasodilation and Bronchodilation.
Decrease peripheral resistance, uterine tone (tocolysis).
Increase lipolysis, insulin release, heart rate.
Which receptors of the sympathetic nervous system is predominant in the Vasculature to skeletal muscle?
Alpha 1 and Beta 2 receptors (Beta 2 Predominance)
Which receptors of the sympathetic nervous system is predominant in the heart?
Beta 1 receptors
Which receptors of the sympathetic nervous system is predominant in the lungs?
Beta 2 receptors.
What are the types of Sympathomimetics?
Direct and indirect.
Which are the characteristics of the direct Sympathomimetics?
Bind to Adrenergic receptors, and No interaction with presynaptic neuron.
Which are the characteristics of the Epinephrine?
Direct sympathomimetic drug, which alpha effects predominate at high doses, and stronger effect at Beta 2- receptor than norepinephrine.
In which cases can we use epinephrine?
Anaphylaxis, asthma, Croup, hypotension and open-angle glaucoma.
Which are the characteristics of Norepinephrine?
Alpha1 > alpha 2 > Beta 1
In which cases can we use a norepinephrine?
Hypotension (but increase renal perfusion), 1st line in Treatment for Septic and Cariogenic shock