Video 3 Sympathetic Activation Flashcards

1
Q

Which are the sympathetic nervous system receptors?

A

Alpha: 1 & 2.
Beta: 1 & 2.

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2
Q

What is the effect of the sympathetic nervous system on the eyes? And which receptor is used?

A

Alpha1: Increase the pupillary dilator muscle contraction (Mydriasis).
Alpha2: Decrease aqueous humor production.
Beta2: Increase aqueous humor production.

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3
Q

What is the effect of the sympathetic nervous system on the vascular system? And which receptor is used?

A

Alpha1: Increase vascular smooth muscle contraction.
Beta2: Cause Vasodilation.

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4
Q

What is the effect of the sympathetic nervous system on the pressure? And which receptor is used?

A

Alpha1: Increase peripheral resistance and blood pressure.

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5
Q

What is the effect of the sympathetic nervous system on the GI tract and GU? And which receptor is used?

A

Alpha1: increase intestinal and bladder sphincter muscle contraction.

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6
Q

What are the functions of the Alpha 2 receptor in the, sympathetic pathetic nervous system?

A

Decrease insulin release, lipolysis.

Increase platelet aggregation.

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7
Q

Which are the effects of the sympathetic Beta 1 receptors?

A

Tachycardia, increase lipolysis, myocardial contractility and release of renin.

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8
Q

What are the effects of Beta 2 receptors?

A

Vasodilation and Bronchodilation.
Decrease peripheral resistance, uterine tone (tocolysis).
Increase lipolysis, insulin release, heart rate.

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9
Q

Which receptors of the sympathetic nervous system is predominant in the Vasculature to skeletal muscle?

A

Alpha 1 and Beta 2 receptors (Beta 2 Predominance)

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10
Q

Which receptors of the sympathetic nervous system is predominant in the heart?

A

Beta 1 receptors

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11
Q

Which receptors of the sympathetic nervous system is predominant in the lungs?

A

Beta 2 receptors.

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12
Q

What are the types of Sympathomimetics?

A

Direct and indirect.

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13
Q

Which are the characteristics of the direct Sympathomimetics?

A

Bind to Adrenergic receptors, and No interaction with presynaptic neuron.

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14
Q

Which are the characteristics of the Epinephrine?

A

Direct sympathomimetic drug, which alpha effects predominate at high doses, and stronger effect at Beta 2- receptor than norepinephrine.

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15
Q

In which cases can we use epinephrine?

A

Anaphylaxis, asthma, Croup, hypotension and open-angle glaucoma.

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16
Q

Which are the characteristics of Norepinephrine?

A

Alpha1 > alpha 2 > Beta 1

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17
Q

In which cases can we use a norepinephrine?

A

Hypotension (but increase renal perfusion), 1st line in Treatment for Septic and Cariogenic shock

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18
Q

Which are the characteristics of Isoproterenol?

A

B1=B2, electrophysiologic evaluation of tachyarrhythmias, can worsen ischemia.

19
Q

In Accord with the doses of Dopamine which receptor is stimulated by low, medium and high doses?

A

Low: D1=D2.
Medium: Beta 1&2.
High: Alpha 1&2.

20
Q

Which of the direct Sympathomimetic drugs is used in a stress testing?

A

Dobutamine, beta 1 receptor

21
Q

Which are the applications of Phenylephrine?

A

Hypotension (Vasocontrictor), ocular procedures (Mydriatic), rhinitis (Decongestant). Alpha 1

22
Q

Which of the direct Sympathomimetics drugs is used for acute asthma and long asthma too?

A

Albuterol for acute asthma; Salmeterol for long-term asthma or COPD control. B2>B1

23
Q

Which are the characteristics of the terbutaline?

A

B2>B1, Bronchospasms and Tocolysis.

24
Q

What are the characteristics of Clonidine?

A

It is an Alpha 2 agonist, stimulate only alpha 2 receptors, negative feedback mechanism.

25
Q

Which a re the characteristics of the indirect Sympathomimetics ?

A

Norepinephrine release from the presynaptic terminal and inhibit norepinephrine uptake.

26
Q

What are the characteristics of Amphetamine?

A

Indirect general agonist, reuptake inhibitor and also releases stored catecholamines. Clinical applications: Narcolepsy, obesity and Atention Deficit Disorder.

27
Q

What are the characteristics of Ephedrine?

A

Indirect general agonist, release stored catecholamines; clinical applications: Nasal decongestion, urinary incontinence, hypotension.

28
Q

What are the characteristics of Cocaine?

A

Reuptake inhibitor. Cause vasoconstriction and local anesthesia.
Never give B-blockers if cocaine intoxication is suspected (can lead to unopposed alpha 1 activation and extreme hypertension).

29
Q

Which receptors are stimulated by Clonidine?

A

A2

30
Q

Which receptors are stimulated by dopamine?

A

D1=D2>Beta>alpha.

31
Q

Which receptors are stimulated by Phenylephrine ?

A

A1>A2

32
Q

Which receptors are stimulated by Albuterol?

A

B2>B1

33
Q

Which receptors are stimulated by norepinephrine ?

A

A1,A2 and B1

34
Q

Which receptors are stimulated by Isoproterenol ?

A

B1 and B2

35
Q

Which receptors are stimulated by epinephrine ?

A

Alpha and beta

36
Q

Which receptors are stimulated by dobutamine?

A

B1>B2

37
Q

Which receptors are stimulated by Terbutaline?

A

B2>B1

38
Q

Which sympathomimetic given as nebulizer for asthma?

A

Albuterol or levalbuterol.

39
Q

Which sympathomimetic drug choice for anaphylaxis?

A

Epinephrine

40
Q

Which sympathomimetic is the most common first line agent for patients in septic shock?

A

Norepinephrine

41
Q

Which sympathomimetic given subQ for asthma?

A

Terbutaline

42
Q

Which sympathomimetic is used by ENT to Vasocontrict nasal vessels?

A

Phenylephrine, cocaine.

43
Q

What is the primary neurotransmitter released by Adrenergic neurons?

A

Norepinephrine

44
Q

Which of the following medical conditions can be treated with an epinephrine injection? A)bipolar disorder.
B)High blood pressure.
C)Anaphylactic shock.
D)Erectile dysfunction.

A

C) Anaphylactic shock.