Video: 15.3 IP Signaling

Question 1

IP2 is activated by what?

Answer 1

activated GPCR

Question 2

What is the order cascade of IP signaling?

Answer 2

GPCR activates Gq subunit, GDP to GTP, then the two subunits dissociate and activate phospholipase C-Beta, then activated dissociated subunits split IP2 into DAG and IP3, then IP3 binds to calcium channel on ER membrane, opening and releasing calcium into the cytosol, then the increased CA2+ conc. causes PKC binds to DAG activating PKC to phosphorolate target protein (ATP to ADP)

Question 3

Split IP2 becomes what?

Answer 3

DAG and IP3

Question 4

What happens to IP3?

Answer 4

binds to calcium channel at the ER membrane to release CA2+ into cytosol

Question 5

What happens to DAG?

Answer 5

binds to PKC in combination with CA2+ and activates PKC to phosphorolate target protein converting ATP to ADP