Ch 20C Assignment Flashcards
Abl kinase is made hyperactive in CML by which of the following mechanisms?
Group of answer choices
Deletion of the C-terminus of Abl.
Substitution of N-terminus of Abl with Bcr fragment.
Replacement of most of Bcr C-terminus with Abl.
Substitution of Abl C-terminus with Bcr C-terminus.
Substitution of N-terminus of Abl with Bcr fragment.
Secondary mutations in the kinase domain of Bcr-Abl that prevent the binding of Imatinib……
Group of answer choices
lead to better treatment.
lead to resistance to imatinib.
lead to inactivation of Bcr-Abl kinase activity.
prevent cancer recurrence.
lead to resistance to imatinib.
Which statement is FALSE?
Group of answer choices
Observation of polyps in the colon epithelium of a patient is an indication of a malignant carcinoma.
Progression of colorectal cancer is very slow and normally takes over 10 years to turn into malignancy.
Colorectal cancers are usually diagnosed later in life.
Invasive colorectal cancer cells usually metastasize to lymph nodes via lymphatic vessels and then into the bloodstream.
Observation of polyps in the colon epithelium of a patient is an indication of a malignant carcinoma.
The progression from early adenoma to intermediate adenoma in most cases of colorectal cancers is caused by………..
Group of answer choices
loss of APC
activation of Ras
loss of beta-Catenin
activation of MutS
activation of Ras
Most DNA tumor viruses inhibit these protein products ____.
Group of answer choices
p53 and Rb
Apc and Rb
Brca1 and APC
Ras and PI3K
p53 and Rb
Which of these statements about Human Papilloma Virus is FALSE?
Group of answer choices
It remains as extra chromosomal plasmid till a genetic event causes certain viral genes to integrate into the host chromosome.
As soon as it enters human cells it has to be integrated into the host chromosome.
It can stay in a latent phase as a plasmid for a long time.
It is a DNA virus that causes benign warts in the outer layers of cervical epithelium.
As soon as it enters human cells it has to be integrated into the host chromosome.
In Ames test, the potential mutagen is metabolically activated by mixing it with____.
Group of answer choices
rat liver extract
specially designed test bacteria
culture medium lacking histidine
culture medium containing histidine
rat liver extract
Imatinib has been used to treat patients with CML with much success by targeting____
Group of answer choices
anti-apoptotic proteins.
oncogenic H-Ras signaling.
the antigenic proteins on the surface of leukemia cells.
the ATP-binding pocket of a specific fusion protein.
the ATP-binding pocket of a specific fusion protein.
Development of drugs to target cancers can be aided by understanding the molecular mechanisms that underlie the respective cancers. Which of the following is NOT true regarding such drugs.
Group of answer choices
The drug imatinib (Gleevec®) can inhibit the chimeric tyrosine kinase Bcr-Abl in chronic myelogenous leukemia (CML).
Imatinib is most effective in treating chronic myelogenous leukemia (CML) in its acute blast-crisis phase.
Protein kinases have turned out to be good targets to inhibit with small molecules.
The success of imatinib relies on the phenomenon of oncogene dependence in cancer cells.
Imatinib is most effective in treating chronic myelogenous leukemia (CML) in its acute blast-crisis phase.
For Ames test, special bacteria that lack the ability to grow in the absence of histidine were cultured in media that lacked histidine. However, even after treatment with chemical X, the bacteria were unable to grow in media lacking histidine. The results of the Ames test suggest which of the following:
Group of answer choices
Chemical X is highly mutagenic.
Chemical X is moderately mutagenic.
Chemical X is not mutagenic under conditions tested.
Chemical X is not mutagenic under conditions tested.
Cancer epithelial cells lose their polarity and adhesiveness and become more invasive. This process is called…………
Group of answer choices
epigenetic change
EMT
apoptosis
mitotic recombination
EMT
Which statement about cancer gene alterations is FALSE?
Group of answer choices
Mutations only in the coding regions for genes can drive cancers.
Mutations in the regulatory regions outside of the gene coding regions can also alter gene product.
Chromosomal rearrangements can also alter protein levels and/or activity.
Gene amplification can enhance normal protein production.
Mutations only in the coding regions for genes can drive cancers.
