19 Assignment Flashcards
In animal cells, what part of the cytoskeleton is involved in cell-cell and cell-ECM anchoring?
IF
MT
Actin
IF and MT
IF and actin
IF and actin
If the mouse embryo shown in Q3 were engineered to express and secrete high levels of a small high affinity Ca2+ binding protein, how do you think compaction might be affected?
Accelerated
Unchanged
Delayed
Delayed
To sculpt cells into tissues, cadherin-dependent anchoring junctions use tension-sensitive catenin proteins to assemble linkages to the actin cytoskeleton. What additional protein would you suspect as the tension (force) generator in this system?
Kinesin
Myosin
Vinculin
Dynein
Fimbrin
Myosin
Desmosomes are incredibly strong anchoring junctions that hold onto IF more tightly as more tension is applied. Based on the schematic representation of component proteins below, which protein appear to have the biophysical properties to pull off this feat?
Desmoglein
Desmocolin
Plakophilin
Plakoglobin
Desmoplakin
Desmoplakin
What shape can be traced around the top view of a connexon?
Triangle
Square
Pentagon
Hexagon
Hexagon
Is there any evidence that gap junctions can “open” and “close.”
Yes
No
Yes
Compared to a typical protein, GAGs fold:
about the same
more compactly
less compactly
less compactly
Integrins are versatile transmembrane dimers capable of linking the cytoskeleton to the ECM. Non-epithelial cells use integrins to attach to the RGD motif of:
Elastin
Fibronectin
Laminin
Collagen
Dystroglycan
Fibronectin
The extensive negative charges on GAGs attract:
Flies
Opposites
Mice
Investors
Water
Water
Two basic forms of ECM are cell _____ , _____ connective tissue and cell _____ , _____ basal lamina.
poor, 2-D / rich, 3-D
poor, 3D / rich, 2-D
rich, 3-D / poor, 2-D
rich, 2-D / poor, 3-D
poor, 3D / rich, 2-D
When a cancerous cell fails to sense, grab, and stretch itself into a field of fibronectin it can:
divide
grow
differentiate
All of the choices
All of the choices
When a healthy cell fails to sense, grab, and stretch itself into a field of fibronectin it:
divides
grows
shrinks
dies
differentiates
dies
