Vesicular Dermatoses Flashcards
Herpes Simplex 1
transmitted how?
- viral transmission
- contaminated saliva
- infected body secretions
Herpes Simplex 1
Pathophys
- direct contact at mucosal or skin sites
- viral entry into upper dermis until it reaches sensory & autonomic nerve endings
Herpes Simplex 1
clinical presentation of primary infection
2 components
- most commonly asx
- can cause tonsil pharyngitis or gingivostomatitis
Herpes Simplex 1
clinical presentation of recurrent infection
2 components
- prodromal sx w/in 24 hrs of viral reactivation
- development of grouped vesicles on erythematous base
Herpes Simplex 1
dx
PCR (most sensitive & specific)
Herpes Simplex 1
tx
valacyclovir 2g BID x1d
Herpes Simplex 2
affects what % of the population?
approx 25%
Herpes Simplex 2
pathophys
- sexually transmitted via direct contact
- viral entry into upper dermis until it reaches sensory and autonomic nerve endings
Herpes Simplex 2
clinical presentation
4 components
- prodrome sx
- painful genital ulcers
- vesicles which evolve to pustules
- (+/-) inguinal LAD
Herpes Simplex 2
describe the vesicles
3 components
- multiple, shallow, tender, grouped
- 2-4mm in size
- erythemtous base
Herpes Simplex 2
how do the vesicles progress?
- vesicles
- vesicle pustules, erosions, or alterations
Herpes Simplex 2
dx
- PCR (most sens/spec)
- Tzanck smear (classic, but not specific)
Herpes Simplex 2
what will you see on Tzanck smear?
multi-nucleated giant cells
Herpes Simplex 2
tx options
- acyclovir
- valacyclovir
- famciclovir
Herpes Zoster
reactivation of what?
latent varicella zoster virus infection
Herpes Zoster
where does the virus lie dormant?
- dorsal root ganglia
- terminal ganglia
Herpes Zoster
clinical presentation of prodrome
4
- fever
- malaise
- sensory changes
- rash
Herpes Zoster
clinical presentation of rash
5 components
- unilateral
- vesicular dermatomal eruption
- painful, grouped vesicles
- erythematous base
- does not cross midline
Herpes Zoster
clinical manifestation
2- PPP for boards
- thoracic and lumbar roots most commonly affected
Herpes Zoster
dx
usually clinical
PCR as needed
Herpes Zoster
Tx
- valacyclovir, acyclovir, famiciclovir w/in 72 hrs of sx onset
Herpes Zoster
education to provide to pts on infectiousness
no longer infectious once lesions crust over
Herpes Zoster
prophylaxis for immunocompromised pts
VZV immune globulin
Herpes Zoster
prevention
- Shingrix vax