Venous Thrombosis Flashcards
An arterial thrombus is rich in what?
Platelets
a venous thrombus is rich in what?
Fibrin
Subgroups in virchows triad?
Stasis
Vessel wall
Hypercoagulability
Treatment of venous thrombosis?
Heparin
Warfarin
NOAC
Clinical features of DVT?
Limbs hot, swollen, tender
Pitting oedema
Risk factors for venous thrombo- embolism ?
Age Marked obesity Pregnancy Puerperium Oestrogen therapy Previous DVT/PE Trauma/ surgery Malignancy Paralysis Infection Thrombophilia
What is thrombophilia?
Familial or acquired disorders of homeostatic mechanism likely to predispose to thrombosis
Potential mechanisms in thrombophilia?
Increased coagulation activity
Decreased fibrinolytic activity
Decreased anticoagulant activity
What potential genetic defects involved in hereditary thrombophilia?
Factor V Leiden
Protein c and s deficiency
Antithrombin deficiency
Prothrombin mutation
Management of hereditary thrombophilia?
Advice avoiding risk
Short term prophylaxis
Short term anticoagulants
Long term anticoagulation
Cause acquired thrombophilia?
Anti phospholipid syndrome
Features of antiphospholipid syndrome ?
Recurrent thrombosis
Recurrent fatal loss
Mild thrombocytopenia
Antiphospholipid antibodies are also known as what?
Lupus anticoagulants
Conditions associated with antiphospholipid syndrome?
Autoimmune disorders Lymphoproliferative disorders Viral infections Drugs Primary
How does antiphospholipid syndrome cause haemostasis?
Antibodies lead to conformational change in beta 2 glycoprotein 1 -> activation of primary and secondary haemostasis and vessel wall abnormalities
