Arterial Thombosis And Antiplatelet Drugs

Question 1

Risk factors for arterial thrombosis?

Answer 1

Hypertension
Smoking
High cholesterol
Diabetes

Question 2

How does adhesion of platelets begin?

Answer 2

Platelets bind to sub endothelial collagen via glycoprotein 1b and Von willebrand factor

Question 3

Process of platelet aggregation?

Answer 3

Platelets attach to each other via GP IIbIIIa and fibrinogen

Question 4

Process of platelet activation?

Answer 4

Platelets alter their shape to expose more phospholipid on surface.
Release granules that stimulate platelet activation - thrombin, thrombosis A2 and ADP to recruit more platelet s

Question 5

Action of aspirin?

Answer 5

Inhibits cyclooxygenase

Question 6

Side effects of aspirin ?

Answer 6

Bleeding

GI ulceration / bronchospasm

Question 7

Action of clopidogrel/ prasugrel?

Answer 7

ADP receptor antagonists

Question 8

Action of dipyridamole ?

Answer 8

Phosphodiesterase inhibitor

Question 9

Action of abciximab?

Answer 9

GP IIbIIIa inhibitors - inhibits aggregation

Question 10

What class of drug do you use for an arterial thrombosis?

Answer 10

Anti platelet

Question 11

What type of drug do you use for a venous thrombosis?

Answer 11

Anticoagulant