Cytotoxic Chemotherapy Flashcards
Two types of chemo?
Cell cycle specific
Non-cell cycle specific
Are cell cycle specific chemos tumour specific or not?
Yes, tumour specific
What are the types of cell cycle specific chemotherapies?
Antimetabolites
Mitotic spindle inhibitors
In cell cycle specific agents, is dose or duration more important?
Duration
What is methotrexate?
An Antimetabolite
What is the action of methotrexate?
Inhibits dihydrofolate reductase
What is hydroxyurea and what is its action?
Antimetabolite
Also know as hydroxycarbamide
Impaired deoxynucleotide synthesis
Are non cell cycle specific agents tumour specific?
No. Also damage normal stem cells
Is dose or duration more important in non cell specific agents?
Dose
Examples of non cell specific agents?
Alkylating agents
Cytotoxic antibodies
What is chlorambucil?
An Alkylating agent
Alkylating agent mode of action??
Bind covalently to bases of DNA .
Pride DNA mutation by free radical production
What are anthracyclines?
Cytotoxic antibiotics
Examples of anthracyclines?
Daunorubicin
Doxorubicin
Action of cytotoxic antibodies?
Impairs RNA transcription
Strand breaks in DNA
