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Haematology > Lymphadenopathy And Lymphoma > Flashcards

Lymphadenopathy And Lymphoma Flashcards

1
Q

Differential diagnoses of lymphadenopathy?

A

Lymphoma
Infection
Metastatic cancer
Connective tissue disease - sarcoidosis , SLE

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2
Q

Specific symptoms of lymphoma?

A

Itch without rash
Alcohol induced pain
Fatigue, night sweats, weight loss

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3
Q

Are lymphoma lymph nodes tender?

A

No

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4
Q

Consistency of lymphoma lymph nodes?

A

Rubbery/ soft

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5
Q

Is skin inflamed over lymphoma lymph nodes?

A

No

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6
Q

Investigations to assess lymph node pathology?

A 
Histology microscopic appearances 
Immunohistochemistry
Immunophenotyping 
Genetic analysis 
Molecular analysis
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7
Q

What is Ibnutinib?

A

Inhibitor of cell signalling pathway- overexpression of activation markers in B cell Lymphoma respond well to this

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8
Q

2 main classifications of lymphoma?

A

Hodgkin

Non- Hodgkin

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9
Q

What cells are characteristic in Hodgkin lymphoma?

A

Reed-Sternberg cells

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10
Q

What age group is hodgkins most common in?

A

Adolescents and young adults

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11
Q

What virus does hodgkins have a connection with?

A

EBV

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12
Q

Diagnosis of hodgkins?

A

Lymph node biopsy

Histological exam

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13
Q

Main presentation of hodgkins?

A

Firm, painless swelling of lymph node

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14
Q

Treatment of early stage hodgkins?

A

Brief chemo - ABVD

Followed by field irradiation

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15
Q

Treatment of advanced hodgkins?

A

Cyclical combination chemo - 8 cycles ABVD

With field irradiation at sites of bulk disease

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16
Q

Stage one Hodgkin’s lymphoma?

A

Single lymph node region / extra lymphatic organ or site

17
Q

Stage 2 lymphoma?

A

2 or more lymph node regions on same side of diaphragm

18
Q

Stage 3 Hodgkin’s lymphoma?

A

Lymph node regions on both sides of diaphragm - may also have splenic / extralymphatic involvement

19
Q

Stage 4 Hodgkin’s lymphoma?

A

Diffuse/ disseminate involvement of one or more extralymphatic organs or tissues with/ without associated lymph node involvement

20
Q

What Hodgkin’s lymphoma is most common?

A

B cell

21
Q

What is lymphoma?

A

Disorders caused by malignant proliferations of lymphocytes. They accumulate in lymph nodes causing lymphadenopathy

22
Q

When does non Hodgkin’s lymphoma typically present ?

A

> 40 yrs old

23
Q

Presentation of non Hodgkin’s lymphoma?

A

Painless peripheral lymphadenopathy

24
Q

Investigations or non Hodgkin’s lymphoma?

A

Blood count
Lymph node biopsy
Bone marrow aspiration
CXR, CT

25
Q

Treatment of low grade non Hodgkin’s?

A

Radiotherapy if localised
Chlorambucil in diffuse
Remission maintained with rituximab

26
Q

Management of high grade non Hodgkin’s?

A

R-CHOP - rituximab, cyclophosphamide, hydroxydaunorubicin, oncovin, prednisolone

Haematology (25 decks)

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