The Lymphoid System Flashcards
B cell maturation occurs where?
Bone marrow
T cell maturation occurs where?
Thymus
Primary lymphoid tissues?
Bone marrow
Thymus
Secondary lymphoid tissues?
Lymph nodes Spleen Tonsils Epithelio-lymphoid tissues Bone marrow
Where are lymph nodes located?
Along the course of lymphatic vessels
Efferent vessels leave the hilum of the lymph node and drain to where?
Cisterna chyli/ thoracic duct
Left/right jugular, subclavian or bronchomediastinal trunks
Where is the end of the route in lymph drainage?
Into venous system at junction of right/ left subclavian and jugular veins
Where is lymph filtered before returning to the blood stream?
Node parenchyma
What are the functions of the lymphatic system?
Return lymph to the circulation - fluid homeostasis and preventing accumulation -> oedema
Filter lymph
What is the cell population in lymph nodes?
Lymphocytes - B cells, T cells, NK cells Macrophages APCs Dendritic cells Endothelial cells
What is lymphadenopathy?
Enlarged lymph nodes
What causes lymphadenopathy?
Local inflammation - infection, vaccine, trauma
Systemic inflammation - infection, autoimmune, connective tissue disease
Malignancy - haematological, mets
Sarcoidosis
What are red lines called that extend from an inflamed region?
Lymphangitis
What is generalised lymphadenopathy suggestive of?
Systemic inflammatory process
Widespread malignancy
What artery supplies the spleen?
Splenic artery
