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IC > Vasoactive peptides > Flashcards

Vasoactive peptides Flashcards

1
Q

Vasoconstrictors

A

angiotensin 2, vasopressin, endothelins, neuropeptide Y

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2
Q

vasodilators

A

bradykinin and related kinins, natriuretic peptides, vasoactive intestinal peptide, substance P, neurotensin, calcitonin gene related peptides

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3
Q

what do ace inhibitors end in

A

pril

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4
Q

are ace inhibitors active drugs or pro drugs

A

captopril is the only active drug - the others are pro drugs

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5
Q

ARB ending

A

Sartan

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6
Q

Aliskiren

A

renin inhibitor

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7
Q

bosentan

A

endotehlin receptor antagonist

inhibits ETA and ETB receptors

active IV and orally

use in pulm hypertension

hepatotox, teratogen

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8
Q

phosphoramidon

A

endoothelin converting enzymes inhibitor

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9
Q

substance P

A

rapidly acting vasodilator (also makes endothelium leaky)

binds to neurokinin receptors (NK1/2/3)

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10
Q

aprepitant

A

neurokinin - 1 receptor antagonist

prevents chemotherapy induced emesis

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11
Q

desmopressin/ vasopressin

A

vasopressin receptor agonists

vasopressin = ADH
desmopressin - minimal V1 receptor activities = no vasoconstriction or stimulation of ACTH release

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12
Q

conivaptan

A

vasopressin receptor antagonist

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13
Q

actions of endothelin

A

rapid transient BP decrase - binds to ETB receptors on endothelium and causes release of NO

prolonged increased BP - binds to ETA receptors on vascular SM and cuases vasoconstriction (overall effect)

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14
Q

icatibant

A

kinin receptor B2 antagonists - being experemented to try to quell pain

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15
Q

calcitonin gene related peptide (CGRP)

A

most potent vasodilator discovered yet

release from trigeminal nerves may produce migrane

antagonists are under trial for migrane therapuetics

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16
Q

neuropeptide Y

A

effects in the CNS: feeding

effects in the PNS: vasoconstriction

neuropeptide Y receptor antagonists are under investigation as antihypertensives and anti-obesity agents

17
Q

amapatrilat, sampatrilat, fasidotrilat

A

vasopeptidase inhibitors

new classes of drugs act to inhibit ACE and neutral endopeptidase -> increase levels of natiuretic peptides and decrease angiotensin 2 -> enhance vasodilation and reduce vasoconstriction and increase sodium excretion, also decrease PVR and BP

IC (32 decks)

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