adrenergic antagonists

Question 1

terazosin

Answer 1

alpha 1 selective antagonist

Question 2

yohimbine

Answer 2

alpha 2 selective antagonist

no established clinical role

may be useful in hypotensive emergencies

Question 3

reserpine

Answer 3

adrenergic neuron blocking drug

inhibits VMAT = no packaging of NE = no neuron release

Question 4

tolazoline

Answer 4

nonselective alpha antagonist

Question 5

esmolol

Answer 5

beta1 selective antagonists

rapidly hydrolyzed - HL = 10 min

Question 6

cartelolol

Answer 6

nonselective beta antagonist

significant intrinsic sympathomimetic effects

Question 7

butoxamine

Answer 7

beta 2 selective antagnoist

no clinical application - take away B2 and the bronchioles will collapse down

Question 8

alfuzosin

Answer 8

alpha 1 selective competitive antagonist

good at BPH - may be selective for the prostate somehow

Question 9

labetalol

Answer 9

alpha 1 selective antagonist

Question 10

guanadrel

Answer 10

adrenergic neuron blocking drugs

gets taken up by VMAT slowly and displaces NE = no NE release

Question 11

nadolol

Answer 11

nonselective beta antagonist

long duration of action

good for open angle glaucoma

Question 12

levobunalol

Answer 12

nonselective beta antagonist

Question 13

metipranolol

Answer 13

nonselective beta antagonist

Question 14

propranolol

Answer 14

nonselective beta antagonist

extensive first pass metabolism (low bioavalibility)

Question 15

tamsulosin

Answer 15

alpha 1 selective competitive antagonist

good in BPH - may be selective to the prostate somehow

Question 16

betaxolol

Answer 16

beta1 selective antagonists

Question 17

labetalol

Answer 17

nonselective beta antagonist

reversible alpha 1 antagonist - lowers the BP (the beta blocker helps with the reflex tach

Question 18

metoprolol

Answer 18

beta1 selective antagonists

Question 19

atenolol

Answer 19

beta1 selective antagonists

Question 20

prazosin

Answer 20

alpha 1 selective antagonist

Question 21

phenoxybenzamine

Answer 21

nonselective irreversible alpha antagonist

treatment for pheochromocytoma

postural hypotnesion and tachy limit use

Question 22

nebivolol

Answer 22

beta1 selective antagonists

Question 23

phentolamine

Answer 23

nonselective competitive alpha(1 and 2) antagonist

produces reflex tach

Question 24

timolol

Answer 24

nonselective beta antagonist

long duration of action

use for treatment of open angle glaucoma

Question 25

penbutolol

Answer 25

nonselective beta antagonist

Question 26

bisprolol

Answer 26

beta1 selective antagonists

Question 27

doxazosin

Answer 27

alpha 1 selective antagonist

longer half life

used in hypertension and BPH

Question 28

pindolol

Answer 28

nonselective beta antagonist

significant intrinsic sympathomimetic effects

Question 29

silodosin

Answer 29

alpha 1 selective antagonist

Question 30

acebutolol

Answer 30

beta1 selective antagonists

significant intrinsic sympathomimetic effects (partial agonists)