hypothalamic and pituitary hormone drugs

Question 1

levothyroxine

Answer 1

LT4

take on empty stomach - one hour away from food at least

Question 2

lanreotide

Answer 2

somatostatin analog (SST - inhibits production of GH) = normalizes GH in patisnt with high GH (acromegaly)

can cuase statorrhea and gall stones

Question 3

octreotide

Answer 3

somatostatin analog (SST - inhibits production of GH) = normalizes GH in patisnt with high GH (acromegaly)

can cuase statorrhea and gall stones

Question 4

desmopressin

Answer 4

long lasting ADH analog - used for diabetes insipidus

Question 5

mecasermin

Answer 5

recombinant IGF-1

treat Laron syndrome

SE: hypoglycemia - take meds with a meal

Question 6

hydrocortisone

Answer 6

cortisol analog - short HL

Question 7

cabergoline

Answer 7

D2 receptor agonist

can be used for prolactinoma (helps lower prolactin levels)

Question 8

testosterone cypionate

Question 9

turner syndrome

Answer 9

45X karyotype (they only have one X)

need to give GH before the epi plates close to promote growth to a normal size

Question 10

bromocriptine

Answer 10

D2 receptor agonist

can lower prolactin secretion

better therapy is removal of pituitary adenoma that is secreting prolactin

Question 11

acromegaly

Answer 11

large hands and feet, frontal bossing, coarse facial features

glucose intolerance. diabetes

more common for LV hypertrophy and colonic polyps

diag: high levels of IGF1 - > confirm: glucose load (normally GH should go below 5 - in these peopel there is no response)

these are typically due to pit adenoma - treatment: transsphenoidal surgery and octreotide/lanreotide

Question 12

laron syndrome

Answer 12

GH receptors dont work - depressed growth

the GH levels are high but IGF-1 and IGFBP-3 are low (becuase GH is not able to stimulate secretion)

Question 13

pegvisomant

Answer 13

GH receptor antagonist

may cuase GH to increase

Question 14

dexamethasone

Answer 14

cortisol analog - longer HL