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IC > Gonad hormones > Flashcards

Gonad hormones Flashcards

1
Q

gonadorelin (GnRH)

A

pulasatile release stimulates pituitary gonadotrophs to release LH and FSH

sustained non pulse inhibits LH and FSH release

synthetic GnRH

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2
Q

leuprolide

A

GnRH analog (modified peptide = longer HL)

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3
Q

goserelin

A

GnRH analog (modified peptide = longer HL)

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4
Q

nafarelin

A

GnRH analog (modified peptide = longer HL)

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5
Q

ganirelix

A

GnRH antagonist

same goes for all the other relix drugs

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6
Q

urofillotropin

A

gonadotropin (FSH) analog

found in urine of post men women

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7
Q

fillotropin alfa

A

gonadotropin (FSH) analog

recombinant

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8
Q

lutropin alfa

A

gonadotropin (LH) analog

recombinant

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9
Q

chorionic gonadotropin (hCG)

A

gonadotropin

  • produced by placenta (LH >> FSH)
    • Can activate both LH and FSH receptors but the LH activity is much stronger
      • Can be used to stimulate ovulation and spermatogenesis but mostly its going to make steroid hormones (LH)
    • made by placenta
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10
Q

choriogonadotropin alfa

A

gonadotropin

  • produced by placenta (LH >> FSH)
    • Can activate both LH and FSH receptors but the LH activity is much stronger
      • Can be used to stimulate ovulation and spermatogenesis but mostly its going to make steroid hormones (LH)
    • recombinant
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11
Q

menotropins (hMG)

A

gonadotropin

  • FSH and LH activity (full FSH and LH - does both equally )
    • Human menopausal gonadotropin (hMG)
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12
Q

Estradiol (E2)

A

natural estrogen

major product of the ovary

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13
Q

Estrone (E1)

A

natural estrogen

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14
Q

estriol (E3)

A

natural estrogen

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15
Q

estropitate

A

natural purified crystalized estrone

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16
Q

estrogen cypionate

A

natural estrogen

metabolically resistant prohormones with improved bioavilability and HL

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17
Q

conjugated estrogens

A

natural estrogen

  • Equine (derived from horses) estrogen sulfate sodium salts blended to standardized activity
  • High potency
  • These are technically natural - but they are natural for horses
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18
Q

ethinyl estradiol

A

syntehtic estrogen

  • Undergoes extensive hepatic metabolism
  • More active than natrual estronges
  • Common in oral contraceptives
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19
Q

diethystibestrol

A

estrogen

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20
Q

diethystibestrol (DES)

A

synthetic estrogen

  • Was used to prevent preg complications - but cuased a variety of complications in exposed famale offspring
    • Carcinoma of vagina amoung other things
    • DES daughters - may have to ask women if their mothers were exposed to this drug
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21
Q

esterified estrogens

A

estrogen

22
Q

progesterone

A

progestin

antiestrogenic

antimineralocorticoid

IM

23
Q

medroxyprogesterone

A

progestin

androgenic

antiestrogenic

PO or IM

24
Q

norethindrone

A

progestin

1st gen analog

androgenic

antiestrogenic

anabolic

PO

25
Q

levonorgestrel

A

progestin

plan B

2nd gen

androgenic

antiestrogenic

anabolic

PO

26
Q

desogestrol

A

progestin

3rd gen

little other effects - the cleanest progestin we have

PO

27
Q

drospirenone

A

progestin

estrogenic

antimineralocorticoid

PO

28
Q

tamoxifen

A

SERM

used in breast cancer

29
Q

toremifine

A

SERM - partial agonist partial antagonist

used in breast cancer

30
Q

raloxifene

A

SERM

used in osteoporosis

31
Q

bazedoxefine

A

SERM

used for relieving men symptoms - in combo with conjugated estrogens

32
Q

clomiphene

A

SERM

ovulation induction

increases LH and FSH release by blocking negative feedback by estrogen

this is an oral drug - women who are trying to get preg may try this before some other treatments (hCG) - becuase its easyer to take

33
Q

fulvestrant

A

estrogen antagonist

used in tamoxifen resistant breast cancer

34
Q

mefipristone

A

RU486

  • Post coital contraceptive
  • Abortifacient in combination with misprostol or PGE1 - basically don’t support the pregnancy and expels the conceived embryo
  • Also a glucorticoid antagonist
35
Q

anatrozole

A

aromatase inhibitor (blocks the last enzyme in the path to produce estrogen)

non steroidal

36
Q

letrozole

A

aromatase inhibitor (blocks the last enzyme in the path to produce estrogen)

non steroidal

37
Q

exemestane

A

aromatase inhibitor (blocks the last enzyme in the path to produce estrogen)

steroidal

irreversible - long lasting

38
Q

danazol

A

other estrogen and progesterone inhibitors

used to suppress ovarian function

39
Q

testosterone

A

androgen

1:1 androgen:anabolic activity

40
Q

methyltestosterone

A

androgen

1:1 androgen:anabolic activity

oral

41
Q

fluoxymestrone

A

androgen

1:2 androgen:anabolic activity

oral

42
Q

oxandrolone

A

androgen

1:13 androgen:anabolic activity

most anabolic that we have

the illegal ones are more anabolic

oral

43
Q

testosterone cypionate

A

androgen

testosterone esters

1:1 androgen:anabolic activity

IM

44
Q

ketoconazole

A

Steroid synthesis inhibitor

used for prostate cancer and men with excess testosterone secretion

inhibits gonadal steroid synth - increases estrogen: testosterone ratio -> gynecomastia

45
Q

abiraterone

A

Steroid synthesis inhibitor

used for prostate cancer and men with excess testosterone secretion

17a-hydroxylase inhibitor

46
Q

finasteride

A

Steroid synthesis inhibitor

used for prostate cancer and men with excess testosterone secretion

5a-hydroxylase inhibitor - decreased DHT

47
Q

dutasteride

A

Steroid synthesis inhibitor

used for prostate cancer and men with excess testosterone secretion

5a-hydroxylase inhibitor

long HL

48
Q

cyproterone

A

androgen receptor inhibitor

used for hirsutism in women and excessive sexual desire in men (chemical castration)

49
Q

flutamide

A

competitive antagonist of the androgen receptors

50
Q

spironolactone

A

androgen receptor inhibitor

competes with DHT as well as aldosterone

IC (32 decks)

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