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IC > Gonad hormones > Flashcards

Gonad hormones Flashcards

1
Q

gonadorelin (GnRH)

A

pulasatile release stimulates pituitary gonadotrophs to release LH and FSH

sustained non pulse inhibits LH and FSH release

synthetic GnRH

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2
Q

leuprolide

A

GnRH analog (modified peptide = longer HL)

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3
Q

goserelin

A

GnRH analog (modified peptide = longer HL)

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4
Q

nafarelin

A

GnRH analog (modified peptide = longer HL)

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5
Q

ganirelix

A

GnRH antagonist

same goes for all the other relix drugs

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6
Q

urofillotropin

A

gonadotropin (FSH) analog

found in urine of post men women

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7
Q

fillotropin alfa

A

gonadotropin (FSH) analog

recombinant

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8
Q

lutropin alfa

A

gonadotropin (LH) analog

recombinant

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9
Q

chorionic gonadotropin (hCG)

A

gonadotropin

  • produced by placenta (LH >> FSH)
    • Can activate both LH and FSH receptors but the LH activity is much stronger
      • Can be used to stimulate ovulation and spermatogenesis but mostly its going to make steroid hormones (LH)
    • made by placenta
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10
Q

choriogonadotropin alfa

A

gonadotropin

  • produced by placenta (LH >> FSH)
    • Can activate both LH and FSH receptors but the LH activity is much stronger
      • Can be used to stimulate ovulation and spermatogenesis but mostly its going to make steroid hormones (LH)
    • recombinant
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11
Q

menotropins (hMG)

A

gonadotropin

  • FSH and LH activity (full FSH and LH - does both equally )
    • Human menopausal gonadotropin (hMG)
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12
Q

Estradiol (E2)

A

natural estrogen

major product of the ovary

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13
Q

Estrone (E1)

A

natural estrogen

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14
Q

estriol (E3)

A

natural estrogen

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15
Q

estropitate

A

natural purified crystalized estrone

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16
Q

estrogen cypionate

A

natural estrogen

metabolically resistant prohormones with improved bioavilability and HL

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17
Q

conjugated estrogens

A

natural estrogen

  • Equine (derived from horses) estrogen sulfate sodium salts blended to standardized activity
  • High potency
  • These are technically natural - but they are natural for horses
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18
Q

ethinyl estradiol

A

syntehtic estrogen

  • Undergoes extensive hepatic metabolism
  • More active than natrual estronges
  • Common in oral contraceptives
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19
Q

diethystibestrol

A

estrogen

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20
Q

diethystibestrol (DES)

A

synthetic estrogen

  • Was used to prevent preg complications - but cuased a variety of complications in exposed famale offspring
    • Carcinoma of vagina amoung other things
    • DES daughters - may have to ask women if their mothers were exposed to this drug
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21
Q

esterified estrogens

22
Q

progesterone

A

progestin

antiestrogenic

antimineralocorticoid

IM

23
Q

medroxyprogesterone

A

progestin

androgenic

antiestrogenic

PO or IM

24
Q

norethindrone

A

progestin

1st gen analog

androgenic

antiestrogenic

anabolic

PO

25
levonorgestrel
progestin plan B 2nd gen androgenic antiestrogenic anabolic PO
26
desogestrol
progestin 3rd gen little other effects - the cleanest progestin we have PO
27
drospirenone
progestin estrogenic antimineralocorticoid PO
28
tamoxifen
SERM used in breast cancer
29
toremifine
SERM - partial agonist partial antagonist used in breast cancer
30
raloxifene
SERM used in osteoporosis
31
bazedoxefine
SERM used for relieving men symptoms - in combo with conjugated estrogens
32
clomiphene
SERM ovulation induction increases LH and FSH release by blocking negative feedback by estrogen this is an oral drug - women who are trying to get preg may try this before some other treatments (hCG) - becuase its easyer to take
33
fulvestrant
estrogen antagonist used in tamoxifen resistant breast cancer
34
mefipristone
RU486 * Post coital contraceptive * Abortifacient in combination with misprostol or PGE1 - basically don’t support the pregnancy and expels the conceived embryo * Also a glucorticoid antagonist
35
anatrozole
aromatase inhibitor (blocks the last enzyme in the path to produce estrogen) non steroidal
36
letrozole
aromatase inhibitor (blocks the last enzyme in the path to produce estrogen) non steroidal
37
exemestane
aromatase inhibitor (blocks the last enzyme in the path to produce estrogen) steroidal irreversible - long lasting
38
danazol
other estrogen and progesterone inhibitors used to suppress ovarian function
39
testosterone
androgen 1:1 androgen:anabolic activity
40
methyltestosterone
androgen 1:1 androgen:anabolic activity oral
41
fluoxymestrone
androgen 1:2 androgen:anabolic activity oral
42
oxandrolone
androgen 1:13 androgen:anabolic activity most anabolic that we have the illegal ones are more anabolic oral
43
testosterone cypionate
androgen testosterone esters 1:1 androgen:anabolic activity IM
44
ketoconazole
Steroid synthesis inhibitor used for prostate cancer and men with excess testosterone secretion inhibits gonadal steroid synth - increases estrogen: testosterone ratio -\> gynecomastia
45
abiraterone
Steroid synthesis inhibitor used for prostate cancer and men with excess testosterone secretion 17a-hydroxylase inhibitor
46
finasteride
Steroid synthesis inhibitor used for prostate cancer and men with excess testosterone secretion 5a-hydroxylase inhibitor - decreased DHT
47
dutasteride
Steroid synthesis inhibitor used for prostate cancer and men with excess testosterone secretion 5a-hydroxylase inhibitor long HL
48
cyproterone
androgen receptor inhibitor used for hirsutism in women and excessive sexual desire in men (chemical castration)
49
flutamide
competitive antagonist of the androgen receptors
50
spironolactone
androgen receptor inhibitor competes with DHT as well as aldosterone

IC (32 decks)

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