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IC > Adrenergic pharm random > Flashcards

Adrenergic pharm random Flashcards

1
Q

butoxamine

A

beta 2 selective antagnoist

no clinical application - take away B2 and the bronchioles will collapse down

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2
Q

cocaine

A

indirect sympathomimetic

blocks uptake 1- stops uptake of catecholamines = longer time in the synapse

can be used as local anesthetic - blocks Na channels - differnet MOA and binding site than sympathomimetic effects

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3
Q

salmeterol

A

direct beta 2 selective agonist

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4
Q

levobunalol

A

nonselective beta antagonist

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5
Q

atenolol

A

beta1 selective antagonists

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6
Q

prenalterol

A

direct B1 selective agonist

partial agonist -

incresae CO with less reflex tach - lack of B2 stimulated venous dilation

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7
Q

oxymethoxamine

A

direct A1 selective agonist

used as topical decongestants

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8
Q

prazosin

A

alpha 1 selective antagonist

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9
Q

metoprolol

A

beta1 selective antagonists

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10
Q

labetalol

A

nonselective beta antagonist

reversible alpha 1 antagonist - lowers the BP (the beta blocker helps with the reflex tach

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11
Q

phenoxybenzamine

A

nonselective irreversible alpha antagonist

treatment for pheochromocytoma

postural hypotnesion and tachy limit use

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12
Q

propranolol

A

nonselective beta antagonist

extensive first pass metabolism (low bioavalibility)

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13
Q

dopamine

A

catecholamine

D1

A1 and B1 at high doses

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14
Q

guanabenz

A

direct A2 selective agonist

used as antihypertensive

diminish SNS outflow

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15
Q

methoxamine

A

direct A1 selective agonist

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16
Q

doxazosin

A

alpha 1 selective antagonist

longer half life

used in hypertension and BPH

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17
Q

metipranolol

A

nonselective beta antagonist

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18
Q

nadolol

A

nonselective beta antagonist

long duration of action

good for open angle glaucoma

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19
Q

phentolamine

A

nonselective competitive alpha(1 and 2) antagonist

produces reflex tach

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20
Q

albuterol

A

direct beta 2 selective agonist

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21
Q

tamsulosin

A

alpha 1 selective competitive antagonist

good in BPH - may be selective to the prostate somehow

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22
Q

Ritodrine

A

beta 2 selective agonist

more selective for uterine SM - prevents labor

23
Q

terbutaline

A

direct beta 2 selective agonist

orally avalible - longer lasting

24
Q

dobutamine

A

catecholamine

A1, B1

25
Q

betaxolol

A

beta1 selective antagonists

26
Q

pindolol

A

nonselective beta antagonist

significant intrinsic sympathomimetic effects

27
Q

labetalol

A

alpha 1 selective antagonist

28
Q

guanadrel

A

adrenergic neuron blocking drugs

gets taken up by VMAT slowly and displaces NE = no NE release

29
Q

ephedrine/ pseudoephedrine

A

indirect sympathomimetic

can also act directly on receptors

30
Q

penbutolol

A

nonselective beta antagonist

31
Q

tolazoline

A

nonselective alpha antagonist

32
Q

nebivolol

A

beta1 selective antagonists

33
Q

clonidine

A

direct A2 selective agonist

used as antihypertensive

diminish SNS outflow

34
Q

acebutolol

A

beta1 selective antagonists

significant intrinsic sympathomimetic effects (partial agonists)

35
Q

esmolol

A

beta1 selective antagonists

rapidly hydrolyzed - HL = 10 min

36
Q

tyramine

A

indirect sympathomimetic

high affinity for VMAT - displaces NE from vessicles - NE diffuses into the synapse

can precipitate hypertensive crisis

MAO inhibitors potentiate effects - less breakdown of NE

37
Q

bisprolol

A

beta1 selective antagonists

38
Q

methyldopa

A

direct A2 selective agonist

used as antihypertensive

diminish SNS outflow

39
Q

dobutamine

A

direct B1 selective agonist (also A1)

incresae CO with less reflex tach - lack of B2 stimulated venous dilation

40
Q

norepinephrine

A

catecholamine

A1/2, B1 (no B2) = no vasodilation in skel muscles

compensetory vagal reflexes at low dose - overcome with high dose

41
Q

yohimbine

A

alpha 2 selective antagonist

no established clinical role

may be useful in hypotensive emergencies

42
Q

silodosin

A

alpha 1 selective antagonist

43
Q

alfuzosin

A

alpha 1 selective competitive antagonist

good at BPH - may be selective for the prostate somehow

44
Q

amphetamine

A

indirect sympathomimetic

VMAT puts it in the vessicles instead of NE - NE diffuses out into synapse

methamphetamine - higher cetneral to peripheral effects

45
Q

timolol

A

nonselective beta antagonist

long duration of action

use for treatment of open angle glaucoma

46
Q

guanfacine

A

direct A2 selective agonist

used as antihypertensive

diminish SNS outflow

47
Q

terazosin

A

alpha 1 selective antagonist

48
Q

epinephrine

A

catecholamine

A1/2, B1/2

49
Q

reserpine

A

adrenergic neuron blocking drug

inhibits VMAT = no packaging of NE = no neuron release

50
Q

phenylephrine

A

direct A1 selective agonist

not metabolized by COMT (not a catecholamine) = longer duration of action

can be used as decongestant

51
Q

cartelolol

A

nonselective beta antagonist

significant intrinsic sympathomimetic effects

52
Q

Isoproterenol

A

catecholamine

B1/2

the BP will drop because the B2 receptors are stronger than B1 activation - reflex tach = higher HR than with epi (low dose)

53
Q

methylphenidate

A

indirect sympathomimetic

amphetamine variant - used in ADHD

IC (32 decks)

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