Adrenergic pharm random

Question 1

butoxamine

Answer 1

beta 2 selective antagnoist

no clinical application - take away B2 and the bronchioles will collapse down

Question 2

cocaine

Answer 2

indirect sympathomimetic

blocks uptake 1- stops uptake of catecholamines = longer time in the synapse

can be used as local anesthetic - blocks Na channels - differnet MOA and binding site than sympathomimetic effects

Question 3

salmeterol

Answer 3

direct beta 2 selective agonist

Question 4

levobunalol

Answer 4

nonselective beta antagonist

Question 5

atenolol

Answer 5

beta1 selective antagonists

Question 6

prenalterol

Answer 6

direct B1 selective agonist

partial agonist -

incresae CO with less reflex tach - lack of B2 stimulated venous dilation

Question 7

oxymethoxamine

Answer 7

direct A1 selective agonist

used as topical decongestants

Question 8

prazosin

Answer 8

alpha 1 selective antagonist

Question 9

metoprolol

Answer 9

beta1 selective antagonists

Question 10

labetalol

Answer 10

nonselective beta antagonist

reversible alpha 1 antagonist - lowers the BP (the beta blocker helps with the reflex tach

Question 11

phenoxybenzamine

Answer 11

nonselective irreversible alpha antagonist

treatment for pheochromocytoma

postural hypotnesion and tachy limit use

Question 12

propranolol

Answer 12

nonselective beta antagonist

extensive first pass metabolism (low bioavalibility)

Question 13

dopamine

Answer 13

catecholamine

D1

A1 and B1 at high doses

Question 14

guanabenz

Answer 14

direct A2 selective agonist

used as antihypertensive

diminish SNS outflow

Question 15

methoxamine

Answer 15

direct A1 selective agonist

Question 16

doxazosin

Answer 16

alpha 1 selective antagonist

longer half life

used in hypertension and BPH

Question 17

metipranolol

Answer 17

nonselective beta antagonist

Question 18

nadolol

Answer 18

nonselective beta antagonist

long duration of action

good for open angle glaucoma

Question 19

phentolamine

Answer 19

nonselective competitive alpha(1 and 2) antagonist

produces reflex tach

Question 20

albuterol

Answer 20

direct beta 2 selective agonist

Question 21

tamsulosin

Answer 21

alpha 1 selective competitive antagonist

good in BPH - may be selective to the prostate somehow

Question 22

Ritodrine

Answer 22

beta 2 selective agonist

more selective for uterine SM - prevents labor

Question 23

terbutaline

Answer 23

direct beta 2 selective agonist

orally avalible - longer lasting

Question 24

dobutamine

Answer 24

catecholamine

A1, B1

Question 25

betaxolol

Answer 25

beta1 selective antagonists

Question 26

pindolol

Answer 26

nonselective beta antagonist significant intrinsic sympathomimetic effects

Question 27

labetalol

Answer 27

alpha 1 selective antagonist

Question 28

guanadrel

Answer 28

adrenergic neuron blocking drugs gets taken up by VMAT slowly and displaces NE = no NE release

Question 29

ephedrine/ pseudoephedrine

Answer 29

indirect sympathomimetic can also act directly on receptors

Question 30

penbutolol

Answer 30

nonselective beta antagonist

Question 31

tolazoline

Answer 31

nonselective alpha antagonist

Question 32

nebivolol

Answer 32

beta1 selective antagonists

Question 33

clonidine

Answer 33

direct A2 selective agonist used as antihypertensive diminish SNS outflow

Question 34

acebutolol

Answer 34

beta1 selective antagonists significant intrinsic sympathomimetic effects (partial agonists)

Question 35

esmolol

Answer 35

beta1 selective antagonists rapidly hydrolyzed - HL = 10 min

Question 36

tyramine

Answer 36

indirect sympathomimetic high affinity for VMAT - displaces NE from vessicles - NE diffuses into the synapse can precipitate hypertensive crisis MAO inhibitors potentiate effects - less breakdown of NE

Question 37

bisprolol

Answer 37

beta1 selective antagonists

Question 38

methyldopa

Answer 38

direct A2 selective agonist ## Footnote used as antihypertensive diminish SNS outflow

Question 39

dobutamine

Answer 39

direct B1 selective agonist (also A1) incresae CO with less reflex tach - lack of B2 stimulated venous dilation

Question 40

norepinephrine

Answer 40

catecholamine A1/2, B1 (no B2) = no vasodilation in skel muscles compensetory vagal reflexes at low dose - overcome with high dose

Question 41

yohimbine

Answer 41

alpha 2 selective antagonist no established clinical role may be useful in hypotensive emergencies

Question 42

silodosin

Answer 42

alpha 1 selective antagonist

Question 43

alfuzosin

Answer 43

alpha 1 selective competitive antagonist good at BPH - may be selective for the prostate somehow

Question 44

amphetamine

Answer 44

indirect sympathomimetic VMAT puts it in the vessicles instead of NE - NE diffuses out into synapse methamphetamine - higher cetneral to peripheral effects

Question 45

timolol

Answer 45

nonselective beta antagonist long duration of action use for treatment of open angle glaucoma

Question 46

guanfacine

Answer 46

direct A2 selective agonist ## Footnote used as antihypertensive diminish SNS outflow

Question 47

terazosin

Answer 47

alpha 1 selective antagonist

Question 48

epinephrine

Answer 48

catecholamine A1/2, B1/2

Question 49

reserpine

Answer 49

adrenergic neuron blocking drug inhibits VMAT = no packaging of NE = no neuron release

Question 50

phenylephrine

Answer 50

direct A1 selective agonist not metabolized by COMT (not a catecholamine) = longer duration of action can be used as decongestant

Question 51

cartelolol

Answer 51

nonselective beta antagonist significant intrinsic sympathomimetic effects

Question 52

Isoproterenol

Answer 52

catecholamine B1/2 the BP will drop because the B2 receptors are stronger than B1 activation - reflex tach = higher HR than with epi (low dose)

Question 53

methylphenidate

Answer 53

indirect sympathomimetic amphetamine variant - used in ADHD