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Y2 MSK > Vasculitis > Flashcards

Vasculitis Flashcards

1
Q

general presentation of vasculitis

A

myalgia, arthralgia, arthritis, fever >38, wt loss, malaise

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2
Q

what is ANCA and what are the names of the types

A

Ab expressed by endothelium against neutrophil granulocyte

types: cytoplasmic, perinuclear

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3
Q

what test is used to detect ANCA

A

immunofluorescence

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4
Q

what does ANCA stand for

A

anti-neutrophil cytoplasmic ab

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5
Q

what score is used to monitor vasculitis

A

Birmingham vasculitis score

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6
Q

causes of secondary causes of vasculitis

A

infection, drug, toxin, inflammatory disorder e.g. cancer

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7
Q

broad categories of vasculitis

A

large vessel
medium vessel
small vessel

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8
Q

types of large vessel vasculitis

A

Takayasu arteritis

Giant cell arteritis

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9
Q

difference in age of presentation for large vessel vasculitis

A

Takayasu arteritis: <40yrs

Giant cell arteritis: >50yrs

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10
Q

condition associated with large vessel vasculitis

A

polymyalgia rheumatica

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11
Q

age, gender and race that are risk factors for takayasu’s arteritis

A

japanese female aged 20 - 40

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12
Q

general presentation of takayasu’s arterities

A

dizzy, vision change, weak arm pulses, weight loss, aortic regurg, HTN/IHD

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13
Q

blood tests for takayasu’s arteritis

A

ESR, CRP

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14
Q

imaging for takayasu’s arteritis

A

MRI / PET CT

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15
Q

management of takayasu’s arteritis

A

prednisolone

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16
Q

examples of medium vessel vasculitis

A

kawasaki’s disease, polarteritis nodosa PAN

17
Q

auto-antibody for kawasaki’s disease

vessels commonly affected by kawasaki’s disease

A

anti-endothelial ab

often coronary arteries

18
Q

age group affected by kawasaki’s disease

A

mainly children

19
Q

polyarteritis nodosa management

A

corticosteroids +- cyclophosphamide

20
Q

“necrotizing lesions, aneurysm, segmental transmural inflam + fibrinoid necrosis” describes pathology of which disease

A

polyartitis nodosa PAN

21
Q

categories of small vessel vasculitis

A

ANCA associated and immune complex

22
Q

examples of immune complex mediated small vessel vasculitis

A

cryoglobulinaemia, HSP, SLE, Goodpasture’s

23
Q

autoantibodies for GPA

A

cANCA, anti-PR3

24
Q

pathology of GPA

A

granulomatosis, necrotizing glomerulonephritis, retinal thrombosis

25
Q

male, resp tract ulcer, sinusitis, nasal crust, epistaxis, deaf, otitis media, saddle nose, haemoptysis, cough, purpura, cranial nerve palsy, conjunctivitis, proptosis, uveitis

A

Wegener’s GPA polyangitis

26
Q

investigations for GPA

A

CXR, urinalysis (proteinurea), autoantibodies

27
Q

examples of anca associated small vessel vasculitis

A

wegener’s GPA polyangitis
microscopic polyangitis MPA
churg strauss EGPA

28
Q

autoantibodies for microscopic polyangitis mpa

A

pANCA, anti-MPO

29
Q

microscopic polyangitis mpa pathology

A

necrotizing glomerulonephritis, no granulomas

30
Q

what is pauci immune vasculitis

A

ANCA associated small vessel vasculitis

31
Q

what is the difference between the presentation of GPA & EGPA

A

EGPA has later onset and asthma and no eye/ENT involvement

32
Q

autoantibodies for EGPA

A

pANCA, anti-MPO

33
Q

gender GPA more common in

A

males

34
Q

what areas of the body are affected by PAN

A

at vessel bifurcation skin/gut/kidney, spares lung

35
Q

what immune component is affected by Henoch-Schonlein purpura

A

IgA

36
Q

age group affected by Henoch-Schonlein purpura

A

children, occasionally adults

37
Q

predisposing factor sometimes present in HSP

A

strep URTI 1-3 weeks before

38
Q

presentation of HSP

A

purpuric rash on feet / buttocks / extensor surfaces plus glumerulonephritis +- abdo pain

39
Q

management of HSP

A

self limiting, supportive

Y2 MSK (20 decks)

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