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Y2 MSK > Connective Tissue Diseases > Flashcards

Connective Tissue Diseases Flashcards

1
Q

are all connective tissue diseases autoimmune

A

yes

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2
Q

gender more affected by lupus and why

A

women since increased estrogen

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3
Q

race more affected by lupus

A

asian

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4
Q

virus linked to lupus

A

epstein barr

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5
Q

most common age of lupus presentation

A

20 - 30

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6
Q

what type hypersensitivity is lupus

A

iii

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7
Q

systemic symptoms in lupus

A

malaise, weight loss, fatigue, fever

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8
Q

dermatological symptoms of lupus

A

malar butterfly rash, photosensitivity, non-scarring alopecia, discoid lupus

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9
Q

cardiovascular symptoms of lupus

A

> PE and MI risk

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10
Q

serositis due to lupus can present as what

A

pericarditis, pleurisy, pleural effusion

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11
Q

rheumatological symptoms of lupus

A

synovitis, polyarthritis

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12
Q

what is the distribution of arthritis in lupus

A

same as RA

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13
Q

1st investigation for lupus

A

urinalysis

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14
Q

imaging for lupus

A

CXR, CT chest, MRI brain

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15
Q

blood tests for lupus

A

FBC, U&E, complement, autoantibodies

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16
Q

what autoantibodies are found in lupus

A 
ANA
anti-dsDNA
anti-Sm
antiphospholipid
RNP
anti-Ro
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17
Q

which autoantibody is specific to lupus

A

anti-Sm (however low sensitivity)

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18
Q

medications for all lupus patients

A

hydroxychloroquine + analgesia

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19
Q

side effect of hydroxychloroquine

A

retinopathy

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20
Q

management of skin disease in lupus

A

TOP CCS

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21
Q

management of arthritis in lupus

A

PO CCS, azathioprine / methotrexate

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22
Q

management of severe lupus (kidney or CNS involvement)

A

IV CCS, cyclophosphamide

23
Q

last line management of lupus

A

IV immunoglobulin, rituximab

24
Q

what is used to monitor lupus that positively correlates with disease activity

A

anti-dsDNA

25
what is used to monitor lupus that negatively correlates with disease activity
complement C3 / C4
26
red flag for antiphospholipid syndrome
recurrent miscarriage
27
pathology of antiphospholipid syndrome
recurrent venous and arteriol thrombosis
28
gender thats a risk factor for antiphospholipid syndrome
women
29
what sign is seen on the skin in antiphospholipid syndrome
livedo reticularis
30
autoantibodies in antiphospholipid syndrome
anti-cardiolipid Ab lupus anticoagulant anti-beta 2 glycoprotein
31
management of antiphospholipid syndrome
lifelong anticoagulant warfarin
32
conditions associated with sjogren's syndrome
RA, SLE, Raynaud's
33
pathology of sjogren's syndrome
lymphocytic infiltration of exocrine glands
34
ages that are risk factors for sjogren's syndrome
40 - 60
35
gender thats a risk factor for sjogren's syndrome
female
36
general presentation of sjogren's syndrome
arthralgia, dry mouth/eye/skin/vagina (sicca)
37
which specific organs can sometimes be affected by sjogren's syndrome
lung, kidney, liver
38
investigations for sjogren's syndrome
schirmer's test, autoantibodies, salivary gland biopsy
39
what does schirmer's test measure
tear production
40
what autoantibodies are found in sjogren's syndrome
anti-ro anti-la ANA
41
what is the name of the limited (cutaneous) form of systemic sclerosis
CREST syndrome
42
what does CREST stand for in CREST syndrome
``` calcinosis raynaud's eosphageal dysmotility schlerodactyly telangiectasia ```
43
what autoantibodies are present in the limited form of systemic slerosis (CREST syndrome)
anti-centromere | ANA
44
what gender is more commonly affected by systemic slerosis
women
45
what ages are risk factors for systemic sclerosis
middle age
46
how does the presentation of the limited and diffuse form of systemic sclerosis differ
limited: only cutaneous in peripheral limbs. diffuse: cutaneous over whole body, rapid onset, can affect lung, heart, kidney, pancreas
47
what autoantibodies are found in diffuse type systemic sclerosis
anti-Scl-70 | ANA
48
maangement of raynaud's disease
CCB
49
management of renal disease in diffuse systemic sclerosis
ACEI
50
management of pulmonary disease in diffuse systemic sclerosis
cyclophosphamide, prednisolone
51
what is mixed connective tissue disease
mixed features of systemic sclerosis, lupus and polymyositis
52
autoantibodies in mixed connective tissue disease
anti-U1-RNP | ANA
53
managment of sjogrens syndrome
eyedrop, saliva replacement, hydroxychloroquine, pilocarpine
54
drug for sjogren's syndrome if organ involvement
DMARD

Y2 MSK (20 decks)

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