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Y2 MSK > Inflammatory Myopathiess > Flashcards

Inflammatory Myopathiess Flashcards

1
Q

what does myositis refer to

A

striated muscle inflammation

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2
Q

what 2 conditions are due to myositis

A

polymyositis and dermatomyositis

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3
Q

what causes polymyositis

A

autoimmune

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4
Q

what causes dermatomyositis

A

autoimmune or paraneoplasitc

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5
Q

age and gender affected by polymyositis

A

female age 40 - 50

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6
Q

age and gender affected by dermatomyositis

A

female age 40 - 50

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7
Q

what conditions are associated with dermatomyositis and polymyositis

A

Raynaud’s, interstitial lung disease, malignancy

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8
Q

what component of the immune system is dysfunctioning in polymyositis

A

CD8

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9
Q

what component of the immune system is dysfunctioning in dermatomyositis

A

CD4

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10
Q

how does myositis present

A

myalgia, arthralgia, dysphagia, dysphonia, fever, myocarditis

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11
Q

how does the presentation of polymyositis and dermatomyositis differ

A

dermatomyositis also has cutaneous presentation

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12
Q

how does dermatomyositis affect the skin

A

Gottron’s papule
heliotrope (purple) oedematous rash around eyes
Shawl sign

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13
Q

what is shawl sign

A

erythematous rash on upper back

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14
Q

where are gottron’s papules found

A

around MCP and PIP joints

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15
Q

autoantibodies in polymyositis and dermatomyositis

A

ANA
anti-Jo-1
anti-SRP
anti-RNP

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16
Q

blood tests for dermatomyositis and polymyositis

A

autoantibodies, CK, ALT, AST

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17
Q

imaging for dermatomyositis and polymyositis

A

MRI

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18
Q

additional tests (not imaging or blood tests) for dermatomyositis and polymyositis

A

electromyogram

muscle biopsy

19
Q

management of polymyositis and dermatomyositis

A

prednisolone +- DMARD/biologic

20
Q

which muscles are mainly affected by polymyositis and dermatomyositis

A

proximal muscles

21
Q

which muscles are mainly affected by inclusion body myositis

A

distal muscles e.g. wrist, finger

22
Q

dermatomyositis and polymyositis are progressive. true or false

A

true

23
Q

dermatomyositis and polymyositis are symmetrical. true or false

A

true

24
Q

inclusion body myositis is symmetrical. true or false

A

false; asmmetrical

25
Q

age and gender affected by inclusion body myositis

A

men over 50

26
Q

age affected by polymyalgia rheumatica

A

over 50

27
Q

condition associated with polymyalgia rheumatica

A

giant cell arteritis

28
Q

what areas of the body are affected by polymyalgia rheumatica

A

shoulder and hip

29
Q

is polymyalgia rheumatica rapid or insidious onset

A

rapid

30
Q

is polymyalgia rheumatica symmetric

A

yes

31
Q

does polymyalgia cause weak or stiff muscles? or bothh

A

only stiff

32
Q

systemic presentation of polymyalgia rheumatica

A

fatigue and weight loss

33
Q

blood tests for polymyalgia rheumatica

A

ESR, PV, CRP (all raised)

34
Q

how is polymyalgia rheumatica diagnosed

A

by exclusion

35
Q

management of polymyalgia rheumatica

A

15mg prednisolone

36
Q

age and gender most affected by fibromyalgia

A

young/middle age women

37
Q

conditions linked to fibromyalgia

A

depression, IBS, SLE, RA

38
Q

presentation of fibromyalgia

A

sleep disturbance, memory problems, diffuse pain, night sweats

39
Q

what is seen on examination in fibromyalgia

A

tender

40
Q

how is fibromylagia diagnosed

A

by exclusion

41
Q

how long must symptoms have been present for a fibromyalgia diagnosis

A

3 months

42
Q

management of fibromyalgia

A

CBT, anti-depressant, analgesia

43
Q

blood tests for fibromyalgia

A

normal inflam markers (PV, CRP, ESR)

Y2 MSK (20 decks)

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