Inflammatory Myopathiess Flashcards
what does myositis refer to
striated muscle inflammation
what 2 conditions are due to myositis
polymyositis and dermatomyositis
what causes polymyositis
autoimmune
what causes dermatomyositis
autoimmune or paraneoplasitc
age and gender affected by polymyositis
female age 40 - 50
age and gender affected by dermatomyositis
female age 40 - 50
what conditions are associated with dermatomyositis and polymyositis
Raynaud’s, interstitial lung disease, malignancy
what component of the immune system is dysfunctioning in polymyositis
CD8
what component of the immune system is dysfunctioning in dermatomyositis
CD4
how does myositis present
myalgia, arthralgia, dysphagia, dysphonia, fever, myocarditis
how does the presentation of polymyositis and dermatomyositis differ
dermatomyositis also has cutaneous presentation
how does dermatomyositis affect the skin
Gottron’s papule
heliotrope (purple) oedematous rash around eyes
Shawl sign
what is shawl sign
erythematous rash on upper back
where are gottron’s papules found
around MCP and PIP joints
autoantibodies in polymyositis and dermatomyositis
ANA
anti-Jo-1
anti-SRP
anti-RNP
blood tests for dermatomyositis and polymyositis
autoantibodies, CK, ALT, AST
imaging for dermatomyositis and polymyositis
MRI
additional tests (not imaging or blood tests) for dermatomyositis and polymyositis
electromyogram
muscle biopsy
management of polymyositis and dermatomyositis
prednisolone +- DMARD/biologic
which muscles are mainly affected by polymyositis and dermatomyositis
proximal muscles
which muscles are mainly affected by inclusion body myositis
distal muscles e.g. wrist, finger
dermatomyositis and polymyositis are progressive. true or false
true
dermatomyositis and polymyositis are symmetrical. true or false
true
inclusion body myositis is symmetrical. true or false
false; asmmetrical
age and gender affected by inclusion body myositis
men over 50
age affected by polymyalgia rheumatica
over 50
condition associated with polymyalgia rheumatica
giant cell arteritis
what areas of the body are affected by polymyalgia rheumatica
shoulder and hip
is polymyalgia rheumatica rapid or insidious onset
rapid
is polymyalgia rheumatica symmetric
yes
does polymyalgia cause weak or stiff muscles? or bothh
only stiff
systemic presentation of polymyalgia rheumatica
fatigue and weight loss
blood tests for polymyalgia rheumatica
ESR, PV, CRP (all raised)
how is polymyalgia rheumatica diagnosed
by exclusion
management of polymyalgia rheumatica
15mg prednisolone
age and gender most affected by fibromyalgia
young/middle age women
conditions linked to fibromyalgia
depression, IBS, SLE, RA
presentation of fibromyalgia
sleep disturbance, memory problems, diffuse pain, night sweats
what is seen on examination in fibromyalgia
tender
how is fibromylagia diagnosed
by exclusion
how long must symptoms have been present for a fibromyalgia diagnosis
3 months
management of fibromyalgia
CBT, anti-depressant, analgesia
blood tests for fibromyalgia
normal inflam markers (PV, CRP, ESR)
