Vancomycin

Question 1

Inhibits biosynthesis of peptidoglycan during cell wall formation by complexing with D-alanyl D-alanine precursor

Answer 1

Vancomycin

Question 2

Bacteriostatic or cidal?

PAE or no PAE?

Answer 2

Cidal

PAE

Question 3

Good or poor absorption from GI tract?

Answer 3

Poor, must be given IV for systemic infections

Question 4

Oral or IV for C. Diff?

Answer 4

Oral

Question 5

Free or limited distribution into body fluids and tissues? CSF?

Answer 5

Free to body fluids and tissues

CSF only with inflammation

Question 6

Excretion?

Answer 6

Renal

Question 7

Desired Peak? Trough?

Indications for higher trough?

Answer 7

20-40
10-20

Endocarditis, osteomyelitis, meningitis

Question 8

Half-life

Answer 8

6-12 hours

Question 9

Red-Man syndrome, maculopapular rash, nephrotoxicity, ototoxicity

Answer 9

Vancomycin

Question 10

Should be used for routine surgical prophylaxis?

Answer 10

No

Question 11

Use for coagulase negative staph in blood culture?

Answer 11

No, contaminated

Question 12

Eradication of MRSA colonization?

Answer 12

No

Question 13

Primary tx of C. diff?

Answer 13

No

Question 14

Common dose

Answer 14

1-15 grams every 12 hrs

Question 15

Oral dose for C. diff

Answer 15

125-500 mg every 6 hrs

Question 16

Glycopeptide antibiotic derived from streptomyces orientalis

Answer 16

Vancomycin