Quinolones Flashcards
Static or cidal?
Cidal
PAE or no PAE?
PAE
1-2 hours
Includes ciprofloxacin, ofloxacin, levofloxacin, moxifloxacin, and gemifloxacin
Quinolones
Ofloxacin, levofloxacin, and moxifloxacin are most
bioavailable
Ofloxacin and levofloxacin are ________ excreted
renally
Can cause photosensitivity. Tendon rupture in conjunction with steroids. Arthropathy
Quinolones
No longer produced. Caused kidney and liver dysfunction
Gatifloxacin
Same generation as ciprofloxacin. Useful for sponataneous bacterial peritonitis
ofloxacin
____________ can double theophylline levels. While ________ has little effect on the levels
Ciprofloxacin
Levofloxacin
Should anatacids, iron, sucralfate, and multivitamins be given within 2-4 hours of quinolone dose?
No
Increase or decrease warfarin anticoagulant effect?
Increase
Potentially doesn’t affect warfarin?
Levofloxacin
Ciprofloxacin and ofloxacin good or bad gram + coverage?
Bad
Levofloxacin, moxifloxacin, and gemifloxacin good or bad staph/strep coverage?
Good
Covers SPACE
Ciprofloxacin and levofloxacin
Covers SACE
Moxifloxacin
Doesn’t cover pseudomonas
Moxifloxacin
Anaerobic coverage
Moxifloxacin only
Cover CMLs (atypicals)
levofloxacin, moxifloxacin, and ciprofloxacin
Be careful of __________ resistance with chlamydia
ciprofloxacin
Ciprofloxacin good or bad gram + coverage?
Bad
Most potent quinolone against gram -s
Ciprofloxacin
Most potent quinolone against pseudomonas
Ciprofloxacin
Excellent bioavailability. Use orally
Ciprofloxacin
Excellent for pencillin resistant strep pnemo
Community acquired pneumonia
excellent bioavailability. Use orally
Levofloxacin, gemifloxacin, and moxifloxacin
Hybrid between ciprofloxacin, gemifloxacin, and moxifloxacin
Levofloxacin
Does NOT cover UTIs
Moxifloxacin
Targets DNA gyrase, topoisomerase II
Quinolones
