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Pharm > Quinolones > Flashcards

Quinolones Flashcards

1
Q

Static or cidal?

A

Cidal

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2
Q

PAE or no PAE?

A

PAE

1-2 hours

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3
Q

Includes ciprofloxacin, ofloxacin, levofloxacin, moxifloxacin, and gemifloxacin

A

Quinolones

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4
Q

Ofloxacin, levofloxacin, and moxifloxacin are most

A

bioavailable

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5
Q

Ofloxacin and levofloxacin are ________ excreted

A

renally

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6
Q

Can cause photosensitivity. Tendon rupture in conjunction with steroids. Arthropathy

A

Quinolones

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7
Q

No longer produced. Caused kidney and liver dysfunction

A

Gatifloxacin

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8
Q

Same generation as ciprofloxacin. Useful for sponataneous bacterial peritonitis

A

ofloxacin

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9
Q

____________ can double theophylline levels. While ________ has little effect on the levels

A

Ciprofloxacin

Levofloxacin

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10
Q

Should anatacids, iron, sucralfate, and multivitamins be given within 2-4 hours of quinolone dose?

A

No

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11
Q

Increase or decrease warfarin anticoagulant effect?

A

Increase

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12
Q

Potentially doesn’t affect warfarin?

A

Levofloxacin

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13
Q

Ciprofloxacin and ofloxacin good or bad gram + coverage?

A

Bad

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14
Q

Levofloxacin, moxifloxacin, and gemifloxacin good or bad staph/strep coverage?

A

Good

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15
Q

Covers SPACE

A

Ciprofloxacin and levofloxacin

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16
Q

Covers SACE

A

Moxifloxacin

17
Q

Doesn’t cover pseudomonas

A

Moxifloxacin

18
Q

Anaerobic coverage

A

Moxifloxacin only

19
Q

Cover CMLs (atypicals)

A

levofloxacin, moxifloxacin, and ciprofloxacin

20
Q

Be careful of __________ resistance with chlamydia

A

ciprofloxacin

21
Q

Ciprofloxacin good or bad gram + coverage?

A

Bad

22
Q

Most potent quinolone against gram -s

A

Ciprofloxacin

23
Q

Most potent quinolone against pseudomonas

A

Ciprofloxacin

24
Q

Excellent bioavailability. Use orally

A

Ciprofloxacin

25
Q

Excellent for pencillin resistant strep pnemo
Community acquired pneumonia

excellent bioavailability. Use orally

A

Levofloxacin, gemifloxacin, and moxifloxacin

26
Q

Hybrid between ciprofloxacin, gemifloxacin, and moxifloxacin

A

Levofloxacin

27
Q

Does NOT cover UTIs

A

Moxifloxacin

28
Q

Targets DNA gyrase, topoisomerase II

A

Quinolones

Pharm (14 decks)

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