Tetracyclines Flashcards

1
Q

static or cidal?

A

Static

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

How is absorption affected by food?

A

Decreased

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

90-100% bioavailable

A

Doxycycline and minocycline

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

58-75% bioavailable

A

tetracycline
demeclocycline
oxytetracycline

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Tetracycline, oxytetracycline, and demeclocyline are ________ excreted

DOT

A

renally

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Doxycycline and minocycline are ___________ excreted

A

biliary

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Can cause photosensitivity, discoloration of teeth, and SIADH

A

tetracyclines

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Reversible diabetes insipidus. Used to treat SIADH

A

Demeclocycline

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Vestibular side effects associated

A

Minocycline

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Causes fanconi-like syndrome with _________ of tetracycline

A

outdated citric acid formulation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Nausea, vomiting, lethargy, polydipsia, polyuria, proteinuria, acidosis, and hypokalemia

A

Fanconi-like syndrome

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Decreased absorption when administered with ________ via _________

A

Di and tri cations (ca, mag, zinc, alum, iron)
Antacids, dairy products
Chelation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Increases or decreases warfarin anticoagulant effects

A

Increases

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Use tetracycline and gentamicin for

A

brucellosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Caused by unpasteurized cheeses and milk.

A

Brucellosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Similar to flu symptoms. Severe infections of CNS or heart lining may occur

A

Brucellosis

17
Q

Acute diarrheal disease. Can lead to severe dehydration in matter of hours

A

V. vibrio/cholera

18
Q

Cause disease with contaminated seafood or wound exposed to seawater

A

V. vulnificus

19
Q

Borrelia burgdorferi also known as

A

lyme disease

20
Q

Bull’s eye rash, fever, headache, muscle and joint pain

A

Lyme disease

21
Q

Use in pregnancy?

A

NO

22
Q

Reversibly binds 30s subunit decreasing protein synthesis

A

tetracyclines