Tetracyclines Flashcards
static or cidal?
Static
How is absorption affected by food?
Decreased
90-100% bioavailable
Doxycycline and minocycline
58-75% bioavailable
tetracycline
demeclocycline
oxytetracycline
Tetracycline, oxytetracycline, and demeclocyline are ________ excreted
DOT
renally
Doxycycline and minocycline are ___________ excreted
biliary
Can cause photosensitivity, discoloration of teeth, and SIADH
tetracyclines
Reversible diabetes insipidus. Used to treat SIADH
Demeclocycline
Vestibular side effects associated
Minocycline
Causes fanconi-like syndrome with _________ of tetracycline
outdated citric acid formulation
Nausea, vomiting, lethargy, polydipsia, polyuria, proteinuria, acidosis, and hypokalemia
Fanconi-like syndrome
Decreased absorption when administered with ________ via _________
Di and tri cations (ca, mag, zinc, alum, iron)
Antacids, dairy products
Chelation
Increases or decreases warfarin anticoagulant effects
Increases
Use tetracycline and gentamicin for
brucellosis
Caused by unpasteurized cheeses and milk.
Brucellosis